A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase

Sonia Gattinoni, Chiara De Simone, Sabrina Dallavalle, Filomena Fezza, Raffaella Nannei, Natalia Battista, Patrizia Minetti, Gianandrea Quattrociocchi, Antonio Caprioli, Franco Borsini, Walter Cabri, Sergio Penco, Lucio Merlini, Mauro MacCarrone

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A series of oxime carbamates have been identified as potent inhibitors of fatty acid amide hydrolase (FAAH), an important regulatory enzyme of the endocannabinoid signaling system. Kinetic analysis indicates that they behave as non-competitive, reversible inhibitors, and show remarkable selectivity for FAAH over the other components of the endocannabinoid system.

Original languageEnglish
Pages (from-to)4406-4411
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number15
DOIs
Publication statusPublished - Aug 1 2010

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Endocannabinoids
Oximes
Carbamates
Kinetics
Enzymes
fatty-acid amide hydrolase

Keywords

  • Endocannabinoids
  • Enzyme inhibitors
  • Fatty acid amide hydrolase (FAAH)
  • Oxime carbamates
  • Synthesis

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase. / Gattinoni, Sonia; Simone, Chiara De; Dallavalle, Sabrina; Fezza, Filomena; Nannei, Raffaella; Battista, Natalia; Minetti, Patrizia; Quattrociocchi, Gianandrea; Caprioli, Antonio; Borsini, Franco; Cabri, Walter; Penco, Sergio; Merlini, Lucio; MacCarrone, Mauro.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 20, No. 15, 01.08.2010, p. 4406-4411.

Research output: Contribution to journalArticle

Gattinoni, S, Simone, CD, Dallavalle, S, Fezza, F, Nannei, R, Battista, N, Minetti, P, Quattrociocchi, G, Caprioli, A, Borsini, F, Cabri, W, Penco, S, Merlini, L & MacCarrone, M 2010, 'A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase', Bioorganic and Medicinal Chemistry Letters, vol. 20, no. 15, pp. 4406-4411. https://doi.org/10.1016/j.bmcl.2010.06.050
Gattinoni, Sonia ; Simone, Chiara De ; Dallavalle, Sabrina ; Fezza, Filomena ; Nannei, Raffaella ; Battista, Natalia ; Minetti, Patrizia ; Quattrociocchi, Gianandrea ; Caprioli, Antonio ; Borsini, Franco ; Cabri, Walter ; Penco, Sergio ; Merlini, Lucio ; MacCarrone, Mauro. / A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase. In: Bioorganic and Medicinal Chemistry Letters. 2010 ; Vol. 20, No. 15. pp. 4406-4411.
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