A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase

Sonia Gattinoni, Chiara De Simone, Sabrina Dallavalle, Filomena Fezza, Raffaella Nannei, Natalia Battista, Patrizia Minetti, Gianandrea Quattrociocchi, Antonio Caprioli, Franco Borsini, Walter Cabri, Sergio Penco, Lucio Merlini, Mauro MacCarrone

Research output: Contribution to journalArticle


A series of oxime carbamates have been identified as potent inhibitors of fatty acid amide hydrolase (FAAH), an important regulatory enzyme of the endocannabinoid signaling system. Kinetic analysis indicates that they behave as non-competitive, reversible inhibitors, and show remarkable selectivity for FAAH over the other components of the endocannabinoid system.

Original languageEnglish
Pages (from-to)4406-4411
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Issue number15
Publication statusPublished - Aug 1 2010



  • Endocannabinoids
  • Enzyme inhibitors
  • Fatty acid amide hydrolase (FAAH)
  • Oxime carbamates
  • Synthesis

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Gattinoni, S., Simone, C. D., Dallavalle, S., Fezza, F., Nannei, R., Battista, N., Minetti, P., Quattrociocchi, G., Caprioli, A., Borsini, F., Cabri, W., Penco, S., Merlini, L., & MacCarrone, M. (2010). A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase. Bioorganic and Medicinal Chemistry Letters, 20(15), 4406-4411. https://doi.org/10.1016/j.bmcl.2010.06.050