A new hypothesis on the pathogenesis of intestinal pseudo-obstruction by intestinal neuronal dysplasia (IND)

Cesare Bosman, Rita Devito, Saverio Fusilli, Renata Boldrini

Research output: Contribution to journalArticlepeer-review

Abstract

Using morphometry and image analysis, we investigated 17 patients showing intestinal pseudo-obstruction secondary to intestinal neuronal dysplasia (IND) and 20 controls. In addition to an increase in the number and size of the ganglia and the ganglionic cells, we also noted a significant increase in NO synthase-containing ganglionic cells. We found that this enzyme, responsible for the synthesis of nitrous oxide caused by oxidation of L-argynine aminoacid, is a neurotransmitter able to induce smooth muscle relaxation by activating cyclic AMP. If the increase in NO synthase-producing ganglionic cells is responsible for the increase in nitrous oxide production, one can hypothesize that an overproduction of nitrous oxide plays a role in the pathogenesis of intestinal pseudo-obstruction secondary to neuronal dysplasia. As NO synthase can be blocked, as was demonstrated by giving L-methil-arginine or N-G-nitro-L-argynine, it might be possible to treat intestinal pseudo-obstruction caused by intestinal neuronal dysplasia at the pharmacological level.

Original languageEnglish
Pages (from-to)789-796
Number of pages8
JournalPathology Research and Practice
Volume197
Issue number12
Publication statusPublished - 2001

Keywords

  • Intestinal neuronal dysplasia IND
  • Intestinal pseudo-obstruction
  • Nitric oxide
  • NO synthase

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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