A New Italian Pedigree With Early-Onset Alzheimer's Disease

Rainero Innocenzo, Lodovico Bergamini, Amalia Cecilia Bruni, Ferini Strambi Luigi, Jean Fransois Foncin, Giorgio Gei, Fabio Macciardi, Maria Paola Montesi, Lorenzo Pinessi, Giovanna Vaula

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We have recently discovered in Torino (Italy) a new pedigree with early-onset Alzheimer's disease. The index patient is a woman who, at the age of 43 years, showed progressive memory impairment and ideomotor apraxia. Several relatives of the patient have had a history of dementia. The ancestors of the patient were from Calabria (southern Italy) and members of the family emigrated to the north of Italy, to France, and to the United States. Up to now, the new kindred comprises 1950 members, distributed in eight generations. Thirty members affected with Alzheimefs disease have been identified. Neuropathologic confirmation of antemortem clinically diagnosed Alzheimer's disease has been achieved for one patient. The pedigree is consistent with autosomal dominant inheritance. The clinical course of the disease is fairly uniform: the first symptom is memory loss, beginning around age 40 years. Psychiatric symptoms like hallucinations and delusions follow. At a later stage of the disease, several patients developed myoclonus and generalized epileptic seizures and eventually died with profound dementia. The “Torino family” shows several genealogic and clinical similarities with other large multigenerational familial Alzheimer's disease pedigrees originating from the Calabria region. (I Geriatr Psychiatry Neurol 1993;628-32).

Original languageEnglish
Pages (from-to)15-18
Number of pages4
JournalJournal of Geriatric Psychiatry and Neurology
Issue number1
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Neurology
  • Geriatrics and Gerontology


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