A new mathematical model to study bone turnover in growing rats

G. Reina, L. Moro, A. Rubinacci, P. Bettica, P. Villani, L. Rovis, G. L. Moro, B. de Bernard, A. Pecile

Research output: Contribution to journalArticlepeer-review


A new mathematical model for the study of bone turnover in growing rats was developed. The model predicts a linear relationship between bone mineral content (BMC) and biochemical markers (BMK) of bone turnover assuming that rats are growing, bone turnover is profoundly affected by skeletal maturation, and resorption and formation are physiologically balanced. The model validation was performed by measuring galactosyl-hydroxylysine (GHYL) and hydroxyproline (HYP) in urines. This mathematical evidence supports our proposed use of the specific bone resorption marker GHYL to predict bone mineral content. Further studies on bone turnover will be possible by the application of the same approach.

Original languageEnglish
Pages (from-to)47-53
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number1
Publication statusPublished - May 29 1992

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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