A new phosphorylcholine-coated polymethylpentene oxygenator for extracorporeal membrane oxygenation: A preliminary experience

M. Pieri, O. G. Turla, M. G. Calabrò, L. Ruggeri, N. Agracheva, A. Zangrillo, F. Pappalardo

Research output: Contribution to journalArticlepeer-review

Abstract

Phosphorylcholine coating has a major role in the improvement of biocompatibility, durability and antihrombogenicity of the circuit for extracorporeal membrane oxygenation (ECMO). Moreover, if heparin-induced thrombocytopenia ensues, removal of all the sources of heparin is challenging if the circuit is coated with heparin.We report our preliminary experience with the new EUROSETS A.L.ONE ECMO oxygenator (Eurosets, Medolla, MO, Italy), which is aimed at providing better biocompatibility thanks to its full coating with phosphorylcholine. We retrospectively collected data on the 16 patients supported with ECMO and with the EUROSETS A.L.ONE ECMO oxygenator at San Raffaele Hospital. Mean ECMO duration was 6 ± 4 days, and 37.5% of the patients died on ECMO. Four episodes of major bleeding and three episodes of minor bleeding were recorded. The oxygenator had an excellent performance in gas exchange and the median pressure drop was 57 (26-85) mmHg at full blood flow (2.5 L/m2/min).The EUROSETS A.L.ONE ECMO oxygenator was an excellent device in our preliminary experience. Further evaluation on a larger sample is encouraged.

Original languageEnglish
Pages (from-to)132-137
Number of pages6
JournalPerfusion
Volume28
Issue number2
DOIs
Publication statusPublished - Mar 2013

Keywords

  • antihrombogenicity
  • biocompatibility
  • extracorporeal membrane oxygenation
  • oxygenator
  • phosphorylcholine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Advanced and Specialised Nursing
  • Safety Research

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