A new point-of-care test for the rapid detection of urinary tract infections

Alyexandra Arienzo, Valentina Cellitti, Valeria Ferrante, Francesca Losito, Ottavia Stalio, Lorenza Murgia, Rossella Marino, Flavia Cristofano, Michela Orrù, Paolo Visca, Salvatore Di Somma, Lorena Silvestri, Vincenzo Ziparo, Giovanni Antonini

Research output: Contribution to journalArticlepeer-review


Urinary tract infections (UTIs) are among the most common infections in all age groups. Fast and accurate diagnosis is essential to ensure a timely and effective therapy. Alongside with reference culture-based methods, several point-of-care tests (POCTs) for early detection of UTIs have been developed, but they have not been significantly implemented in current clinical practice. The Micro Biological Survey (MBS) POCT is a simple test developed by MBS Diagnostics Ltd. (London, UK) for the detection and management of UTIs. The present study has been undertaken to investigate the potentials and limits of the MBS POCT. A total of 349 patients were enrolled in two open-label, monocentric, non-interventional clinical trials in collaboration with an Emergency Medicine department and the outpatient clinic of two hospitals in Rome. Results of urine analysis using the MBS POCT were compared with those of the routine culture-based tests for UTI diagnosis performed by the hospital laboratory. The MBS POCT provided fast results revealing high bacterial count UTIs (≥ 105 CFU/ml) with 97% accuracy, 92% sensitivity, 100% specificity, 99% PPV, and 96% NPV within a 5-h analytical time threshold.

Original languageEnglish
Pages (from-to)325-332
Number of pages8
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Issue number2
Publication statusPublished - Feb 1 2020
Externally publishedYes


  • Diagnosis
  • Infection
  • POCT
  • UTI

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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