A new polymorphism (Ser362Thr) of the L-myc gene is not associated with lung adenocarcinoma risk and prognosis

M. Spinola, B. Conti, F. Ravagnani, A. Fabbri, M. Incarbone, I. Cataldo, E. Pira, C. Pelucchi, C. La Vecchia, T. A. Dragani

Research output: Contribution to journalArticlepeer-review

Abstract

The non-coding variation in the second intron of the L-myc gene, generating an EcoRI polymorphism, is associated with lung cancer risk and prognosis. We carried out sequence analysis of the L-myc gene in lung adenocarcinoma (ADCA) patients to identify functional polymorphisms and identified a new single nucleotide polymorphism (SNP) in the third exon of the gene causing a Ser362Thr conservative amino acid change in the C-terminus of the encoded protein. This polymorphism showed significant linkage disequilibrium with the L-myc EcoRI polymorphism located at 1751 bp distance. Genotyping of the Ser362Thr SNP in 220 Italian ADCA patients and in 230 general population controls revealed a similar low frequency (0.10-0.11) of the Thr allele in both groups. The multivariate odds ratio was 0.68 (95% confidence interval (CI) 0.38-1.22). In the ADCA patients, no significant association between the Ser/Thr polymorphism and survival was observed. Thus, the present results do not support candidacy of the L-myc Ser362Thr polymorphism for the functional polymorphism of the L-myc genomic region.

Original languageEnglish
Pages (from-to)87-89
Number of pages3
JournalEuropean Journal of Cancer Prevention
Volume13
Issue number1
DOIs
Publication statusPublished - Feb 2004

Keywords

  • Adenocarcinoma
  • Alleles
  • Case-control studies
  • Genes
  • Genotype
  • Lung neoplasms
  • myc
  • Polymorphism

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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