A new PRINS technique for a rapid detection of chromosome aneuploidies

Savino Calvano, Giovanni Pio De Cillis, Rosanna Latino, Angelo Notarangelo, Paolo Gasparini, Leopoldo Zelante

Research output: Contribution to journalArticlepeer-review


The primed in situ labeling (PRINS) technique is an alternative method to the traditional Fluorescent in Situ Hybridization technique (FISH) for chromosome anomalyes identification. We developed a new simplified PRINS protocol and applied it to detect DNA alfoid sequences of chromosomes 13, 14, 15, 17, 18, 21, 22, X and Y, either on meta-phase spreads and interphase nuclei. This modified protocol makes PRINS method more rapid for detecting chromosomal aneuploidies.

Original languageEnglish
Pages (from-to)99-102
Number of pages4
JournalMinerva Biotecnologica
Issue number2
Publication statusPublished - Jun 2000


  • Alfoid sequences
  • Aneuploidies

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology


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