A new rat model of small vessel stenting

Ciro Indolfi, Giovanni Esposito, Eugenio Stabile, Luigi Cavuto, Alfonso Pisani, Carmela Coppola, Daniele Torella, Cinzia Perrino, Emilio Di Lorenzo, Antonio Curcio, Lucio Palombini, Massimo Chiariello

Research output: Contribution to journalArticle

Abstract

Objectives: Restenosis is the major complication of coronary angioplasty and stenting. In addition, the small vessel diameter represents a major limitation to the wide use of the technology. The aim of this study was to assess the feasibility and the vascular response of stent deployment in rat small vessels. Methods: In 40 Wistar rats (500-550 g) a Nir stent crimped on a 1.5 mm Comet angioplasty balloon catheter was deployed at high pressure in the common carotid artery. Neointimal area, neointima/media ratio and the arterial dimension were assessed immediately and at 7, 14, 21, and 28 days after stenting. Results: After stent deployment, the neointimal area and the neointima/media ratio increased progressively and peaked at 14 days (p

Original languageEnglish
Pages (from-to)179-185
Number of pages7
JournalBasic Research in Cardiology
Volume95
Issue number3
DOIs
Publication statusPublished - Jun 2000

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Keywords

  • Angioplasty
  • Experimental
  • Pathophysiology
  • Re modeling
  • Restonosis
  • Smooth muscle
  • Stents
  • Vasculature

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Indolfi, C., Esposito, G., Stabile, E., Cavuto, L., Pisani, A., Coppola, C., Torella, D., Perrino, C., Di Lorenzo, E., Curcio, A., Palombini, L., & Chiariello, M. (2000). A new rat model of small vessel stenting. Basic Research in Cardiology, 95(3), 179-185. https://doi.org/10.1007/s003950050180