TY - JOUR
T1 - A New Scale to Evaluate Motor Function in Rett Syndrome
T2 - Validation and Psychometric Properties
AU - Rodocanachi Roidi, Marina Luisa
AU - Isaias, Ioannis Ugo
AU - Cozzi, Francesca
AU - Grange, Francesca
AU - Scotti, Fabrizia Maria
AU - Gestra, Valentina Francesca
AU - Gandini, Alessandra
AU - Ripamonti, Enrico
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Background: We aim to describe and psychometrically validate the Rett Syndrome Motor Evaluation Scale, a 25-item ordinal scale examining (loco-)motor function across six sections: standing, sitting, transitions, walking, running, and walking up or downstairs. Methods: We illustrate the process of item construction and validation, report findings and normative data obtained on a standardization sample of 60 patients with Rett syndrome. We investigate the validity and reliability of the scale and illustrate its psychometric properties using modern multivariate techniques of data analysis. Results: Sixty patients with Rett syndrome were included (all female; mean age 12.45 (S.D. 8.75) years). The multidimensional latent structure of the scale was supported by the results of the confirmatory factor analysis. Rett Syndrome Motor Evaluation Scale showed strong internal consistency reliability as well as excellent inter-rater agreement. The Rett Syndrome Motor Evaluation Scale scores were not predicted by age, but were associated with disease severity, degree of spasticity, and hand dysfunction. We also identified three latent classes with different degrees of impairment. Conclusions: Rett Syndrome Motor Evaluation Scale is a new, valid, and reliable scale that can be introduced in clinical practice when assessing (loco-)motor function in Rett syndrome.
AB - Background: We aim to describe and psychometrically validate the Rett Syndrome Motor Evaluation Scale, a 25-item ordinal scale examining (loco-)motor function across six sections: standing, sitting, transitions, walking, running, and walking up or downstairs. Methods: We illustrate the process of item construction and validation, report findings and normative data obtained on a standardization sample of 60 patients with Rett syndrome. We investigate the validity and reliability of the scale and illustrate its psychometric properties using modern multivariate techniques of data analysis. Results: Sixty patients with Rett syndrome were included (all female; mean age 12.45 (S.D. 8.75) years). The multidimensional latent structure of the scale was supported by the results of the confirmatory factor analysis. Rett Syndrome Motor Evaluation Scale showed strong internal consistency reliability as well as excellent inter-rater agreement. The Rett Syndrome Motor Evaluation Scale scores were not predicted by age, but were associated with disease severity, degree of spasticity, and hand dysfunction. We also identified three latent classes with different degrees of impairment. Conclusions: Rett Syndrome Motor Evaluation Scale is a new, valid, and reliable scale that can be introduced in clinical practice when assessing (loco-)motor function in Rett syndrome.
KW - Confirmatory factor analysis
KW - Latent class analysis
KW - Motor function
KW - Reliability
KW - Rett syndrome
KW - Validity
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U2 - 10.1016/j.pediatrneurol.2019.03.005
DO - 10.1016/j.pediatrneurol.2019.03.005
M3 - Article
AN - SCOPUS:85064756725
JO - Pediatric Neurology
JF - Pediatric Neurology
SN - 0887-8994
ER -