A new short and simple health-related quality of life measurement for paediatric rheumatic diseases: Initial validation in juvenile idiopathic arthritis

Giovanni Filocamo, Benedetta Schiappapietra, Marta Bertamino, Angela Pistorio, Nicolino Ruperto, Silvia Magni-Manzoni, Stefano Lanni, Claudia Saad-Magalhaes, Roberta Galasso, Bianca Lattanzi, Valentina Muratore, Daniela Tani, Alberto Martini, Angelo Ravelli

Research output: Contribution to journalArticle

Abstract

Objective. To develop and validate a new short and simple measure of health-related quality of life (HRQL) in children with juvenile idiopathic arthritis (JIA). Methods. The Paediatric Rheumatology Quality of Life Scale (PRQL) is a 10-item questionnaire that explores HRQL in two domains: physical health (PhH) and psychosocial health (PsH). Validation of the parent proxy report and child self-report versions of the instrument was accomplished by evaluating 472 JIA patients and ~800 healthy children. Validation analyses included assessment of feasibility, face and content validity; construct and discriminative ability; internal structure and consistency; test-retest reliability; responsiveness to clinical change; and minimal clinically important difference. Results. The PRQL was found to be feasible and to possess both face and content validity. The PRQL score correlated in the predicted range with most of the other JIA outcome measures, thereby demonstrating good construct validity, and discriminated well between different levels of disease severity. Assessment of internal structure (factor analysis) revealed that the PhH and PsH subscales identify two unambiguously separated domains. The internal consistency (Cronbach's a) was 0.86. The intraclass correlation coefficient for test-retest reliability was 0.91. The PRQL revealed fair responsiveness, with a standardized response mean of 0.67 in improved patients. Overall, the PRQL appeared to be more able to capture physical HRQL than psychosocial HRQL. Conclusion. The PRQL was found to possess good measurement properties and is, therefore, a valid instrument for the assessment of HRQL in children with JIA. This tool is primarily proposed for use in standard clinical care.

Original languageEnglish
Article numberkeq065
Pages (from-to)1272-1280
Number of pages9
JournalRheumatology
Volume49
Issue number7
DOIs
Publication statusPublished - Mar 24 2010

Keywords

  • Adolescents
  • Children
  • Health-related quality of life
  • Paediatrics
  • Rheumatic diseases

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'A new short and simple health-related quality of life measurement for paediatric rheumatic diseases: Initial validation in juvenile idiopathic arthritis'. Together they form a unique fingerprint.

  • Cite this