Abstract
Natural killer cells from healthy donors express P-glycoprotein on their surface. This molecule is rearranged during the process of cell-mediated cytotoxicity and it appears to be clustered in the cell-to-cell contact regions. By contrast, in HIV-infected subjects this rearrangement is hindered. These results seem to be associated with cytoskeleton network alterations of the cell-mediated killing process occurring in AIDS patients and can contribute to the comprehension of the mechanisms of the natural killer cell deficiency found in these patients.
| Original language | English |
|---|---|
| Pages (from-to) | 19-21 |
| Number of pages | 3 |
| Journal | Immunology Letters |
| Volume | 60 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1998 |
Keywords
- Natural killer
- NK cells
- P-glycoprotein expression
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
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Cauda, R., Lucia, M. B., Ortona, L., Rainaldi, G., Donelli, G., & Malorni, W. (1998). A new, striking morphological alteration of P-glycoprotein expression in NK cells from AIDS patients. Immunology Letters, 60(1), 19-21. https://doi.org/10.1016/S0165-2478(97)00125-9