A new, striking morphological alteration of P-glycoprotein expression in NK cells from AIDS patients

Roberto Cauda, Mothanje Barbara Lucia, Luigi Ortona, Gabriella Rainaldi, Gianfranco Donelli, Walter Malorni

Research output: Contribution to journalArticle

Abstract

Natural killer cells from healthy donors express P-glycoprotein on their surface. This molecule is rearranged during the process of cell-mediated cytotoxicity and it appears to be clustered in the cell-to-cell contact regions. By contrast, in HIV-infected subjects this rearrangement is hindered. These results seem to be associated with cytoskeleton network alterations of the cell-mediated killing process occurring in AIDS patients and can contribute to the comprehension of the mechanisms of the natural killer cell deficiency found in these patients.

Original languageEnglish
Pages (from-to)19-21
Number of pages3
JournalImmunology Letters
Volume60
Issue number1
DOIs
Publication statusPublished - Jan 1998

Keywords

  • Natural killer
  • NK cells
  • P-glycoprotein expression

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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