A new, striking morphological alteration of P-glycoprotein expression in NK cells from AIDS patients

Roberto Cauda; Mothanje Barbara Lucia; Luigi Ortona; Gabriella Rainaldi; Gianfranco Donelli; Walter Malorni

doi:10.1016/S0165-2478(97)00125-9

A new, striking morphological alteration of P-glycoprotein expression in NK cells from AIDS patients

Roberto Cauda, Mothanje Barbara Lucia, Luigi Ortona, Gabriella Rainaldi, Gianfranco Donelli, Walter Malorni

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Natural killer cells from healthy donors express P-glycoprotein on their surface. This molecule is rearranged during the process of cell-mediated cytotoxicity and it appears to be clustered in the cell-to-cell contact regions. By contrast, in HIV-infected subjects this rearrangement is hindered. These results seem to be associated with cytoskeleton network alterations of the cell-mediated killing process occurring in AIDS patients and can contribute to the comprehension of the mechanisms of the natural killer cell deficiency found in these patients.

Original language	English
Pages (from-to)	19-21
Number of pages	3
Journal	Immunology Letters
Volume	60
Issue number	1
DOIs	https://doi.org/10.1016/S0165-2478(97)00125-9
Publication status	Published - Jan 1998

Keywords

Natural killer
NK cells
P-glycoprotein expression

ASJC Scopus subject areas

Immunology
Immunology and Allergy

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10.1016/S0165-2478(97)00125-9

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title = "A new, striking morphological alteration of P-glycoprotein expression in NK cells from AIDS patients",

abstract = "Natural killer cells from healthy donors express P-glycoprotein on their surface. This molecule is rearranged during the process of cell-mediated cytotoxicity and it appears to be clustered in the cell-to-cell contact regions. By contrast, in HIV-infected subjects this rearrangement is hindered. These results seem to be associated with cytoskeleton network alterations of the cell-mediated killing process occurring in AIDS patients and can contribute to the comprehension of the mechanisms of the natural killer cell deficiency found in these patients.",

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author = "Roberto Cauda and Lucia, {Mothanje Barbara} and Luigi Ortona and Gabriella Rainaldi and Gianfranco Donelli and Walter Malorni",

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AU - Cauda, Roberto

AU - Lucia, Mothanje Barbara

AU - Ortona, Luigi

AU - Rainaldi, Gabriella

AU - Donelli, Gianfranco

AU - Malorni, Walter

PY - 1998/1

Y1 - 1998/1

N2 - Natural killer cells from healthy donors express P-glycoprotein on their surface. This molecule is rearranged during the process of cell-mediated cytotoxicity and it appears to be clustered in the cell-to-cell contact regions. By contrast, in HIV-infected subjects this rearrangement is hindered. These results seem to be associated with cytoskeleton network alterations of the cell-mediated killing process occurring in AIDS patients and can contribute to the comprehension of the mechanisms of the natural killer cell deficiency found in these patients.

AB - Natural killer cells from healthy donors express P-glycoprotein on their surface. This molecule is rearranged during the process of cell-mediated cytotoxicity and it appears to be clustered in the cell-to-cell contact regions. By contrast, in HIV-infected subjects this rearrangement is hindered. These results seem to be associated with cytoskeleton network alterations of the cell-mediated killing process occurring in AIDS patients and can contribute to the comprehension of the mechanisms of the natural killer cell deficiency found in these patients.

KW - Natural killer

KW - NK cells

KW - P-glycoprotein expression

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A new, striking morphological alteration of P-glycoprotein expression in NK cells from AIDS patients

Abstract

Keywords

ASJC Scopus subject areas

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