A new synthesis of isoaurones: Cytotoxic activity of compounds related to the alleged structure of isoaurostatin

Eleonora Rizzi, Sabrina Dallavalle, Lucio Merlini, Giovanni Luca Beretta, Graziella Pratesi, Franco Zunino

Research output: Contribution to journal › Article

16 Citations (Scopus)

Abstract

A new synthesis of isoaurones related to the alleged structure of isoaurostatin, via Heck intramolecular cyclization of cinnamic esters of 2-iodophenols, is reported. The cytotoxic activity of these isoaurones is lower than that of the structurally very similar 4-arylcoumarins.

Original languageEnglish
Pages (from-to)4313-4316
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number19
DOIs
Publication statusPublished - Oct 1 2005

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Cyclization
Esters
isoaurostatin
2-iodophenol

Keywords

  • Antitumor activity
  • Arylcoumarins
  • Isoaurones

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

A new synthesis of isoaurones : Cytotoxic activity of compounds related to the alleged structure of isoaurostatin. / Rizzi, Eleonora; Dallavalle, Sabrina; Merlini, Lucio; Beretta, Giovanni Luca; Pratesi, Graziella; Zunino, Franco.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 15, No. 19, 01.10.2005, p. 4313-4316.

Research output: Contribution to journal › Article

Rizzi, E, Dallavalle, S, Merlini, L, Beretta, GL, Pratesi, G & Zunino, F 2005, 'A new synthesis of isoaurones: Cytotoxic activity of compounds related to the alleged structure of isoaurostatin', Bioorganic and Medicinal Chemistry Letters, vol. 15, no. 19, pp. 4313-4316. https://doi.org/10.1016/j.bmcl.2005.06.045
Rizzi E, Dallavalle S, Merlini L, Beretta GL, Pratesi G, Zunino F. A new synthesis of isoaurones: Cytotoxic activity of compounds related to the alleged structure of isoaurostatin. Bioorganic and Medicinal Chemistry Letters. 2005 Oct 1;15(19):4313-4316. https://doi.org/10.1016/j.bmcl.2005.06.045
Rizzi, Eleonora ; Dallavalle, Sabrina ; Merlini, Lucio ; Beretta, Giovanni Luca ; Pratesi, Graziella ; Zunino, Franco. / A new synthesis of isoaurones : Cytotoxic activity of compounds related to the alleged structure of isoaurostatin. In: Bioorganic and Medicinal Chemistry Letters. 2005 ; Vol. 15, No. 19. pp. 4313-4316.
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