A new synthesis of isoaurones

Cytotoxic activity of compounds related to the alleged structure of isoaurostatin

Eleonora Rizzi, Sabrina Dallavalle, Lucio Merlini, Giovanni Luca Beretta, Graziella Pratesi, Franco Zunino

Research output: Contribution to journal › Article

16 Citations (Scopus)

Abstract

A new synthesis of isoaurones related to the alleged structure of isoaurostatin, via Heck intramolecular cyclization of cinnamic esters of 2-iodophenols, is reported. The cytotoxic activity of these isoaurones is lower than that of the structurally very similar 4-arylcoumarins.

Original languageEnglish
Pages (from-to)4313-4316
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number19
DOIs
Publication statusPublished - Oct 1 2005

Fingerprint

Cyclization
Esters
isoaurostatin
2-iodophenol

Keywords

  • Antitumor activity
  • Arylcoumarins
  • Isoaurones

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

A new synthesis of isoaurones : Cytotoxic activity of compounds related to the alleged structure of isoaurostatin. / Rizzi, Eleonora; Dallavalle, Sabrina; Merlini, Lucio; Beretta, Giovanni Luca; Pratesi, Graziella; Zunino, Franco.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 15, No. 19, 01.10.2005, p. 4313-4316.

Research output: Contribution to journal › Article

Rizzi, E, Dallavalle, S, Merlini, L, Beretta, GL, Pratesi, G & Zunino, F 2005, 'A new synthesis of isoaurones: Cytotoxic activity of compounds related to the alleged structure of isoaurostatin', Bioorganic and Medicinal Chemistry Letters, vol. 15, no. 19, pp. 4313-4316. https://doi.org/10.1016/j.bmcl.2005.06.045
Rizzi E, Dallavalle S, Merlini L, Beretta GL, Pratesi G, Zunino F. A new synthesis of isoaurones: Cytotoxic activity of compounds related to the alleged structure of isoaurostatin. Bioorganic and Medicinal Chemistry Letters. 2005 Oct 1;15(19):4313-4316. https://doi.org/10.1016/j.bmcl.2005.06.045
Rizzi, Eleonora ; Dallavalle, Sabrina ; Merlini, Lucio ; Beretta, Giovanni Luca ; Pratesi, Graziella ; Zunino, Franco. / A new synthesis of isoaurones : Cytotoxic activity of compounds related to the alleged structure of isoaurostatin. In: Bioorganic and Medicinal Chemistry Letters. 2005 ; Vol. 15, No. 19. pp. 4313-4316.
@article{28ceea9d88194439a3001953df5e3eee,
title = "A new synthesis of isoaurones: Cytotoxic activity of compounds related to the alleged structure of isoaurostatin",
abstract = "A new synthesis of isoaurones related to the alleged structure of isoaurostatin, via Heck intramolecular cyclization of cinnamic esters of 2-iodophenols, is reported. The cytotoxic activity of these isoaurones is lower than that of the structurally very similar 4-arylcoumarins.",
keywords = "Antitumor activity, Arylcoumarins, Isoaurones",
author = "Eleonora Rizzi and Sabrina Dallavalle and Lucio Merlini and Beretta, {Giovanni Luca} and Graziella Pratesi and Franco Zunino",
year = "2005",
month = "10",
day = "1",
doi = "10.1016/j.bmcl.2005.06.045",
language = "English",
volume = "15",
pages = "4313--4316",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "19",

}

TY - JOUR

T1 - A new synthesis of isoaurones

T2 - Cytotoxic activity of compounds related to the alleged structure of isoaurostatin

AU - Rizzi, Eleonora

AU - Dallavalle, Sabrina

AU - Merlini, Lucio

AU - Beretta, Giovanni Luca

AU - Pratesi, Graziella

AU - Zunino, Franco

PY - 2005/10/1

Y1 - 2005/10/1

N2 - A new synthesis of isoaurones related to the alleged structure of isoaurostatin, via Heck intramolecular cyclization of cinnamic esters of 2-iodophenols, is reported. The cytotoxic activity of these isoaurones is lower than that of the structurally very similar 4-arylcoumarins.

AB - A new synthesis of isoaurones related to the alleged structure of isoaurostatin, via Heck intramolecular cyclization of cinnamic esters of 2-iodophenols, is reported. The cytotoxic activity of these isoaurones is lower than that of the structurally very similar 4-arylcoumarins.

KW - Antitumor activity

KW - Arylcoumarins

KW - Isoaurones

UR - http://www.scopus.com/inward/record.url?scp=23944525888&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23944525888&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2005.06.045

DO - 10.1016/j.bmcl.2005.06.045

M3 - Article

VL - 15

SP - 4313

EP - 4316

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 19

ER -

Access to Document