Abstract
A new synthesis of isoaurones related to the alleged structure of isoaurostatin, via Heck intramolecular cyclization of cinnamic esters of 2-iodophenols, is reported. The cytotoxic activity of these isoaurones is lower than that of the structurally very similar 4-arylcoumarins.
| Original language | English |
|---|---|
| Pages (from-to) | 4313-4316 |
| Number of pages | 4 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 15 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - Oct 1 2005 |
Keywords
- Antitumor activity
- Arylcoumarins
- Isoaurones
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
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Cite this
Rizzi, E., Dallavalle, S., Merlini, L., Beretta, G. L., Pratesi, G., & Zunino, F. (2005). A new synthesis of isoaurones: Cytotoxic activity of compounds related to the alleged structure of isoaurostatin. Bioorganic and Medicinal Chemistry Letters, 15(19), 4313-4316. https://doi.org/10.1016/j.bmcl.2005.06.045