A new theory on the common evolutionary origin of natural immunity, inflammation and stress response: The invertebrate phagocytic immunocyte as an eye-witness

E. Ottaviani, C. Franceschi

Research output: Contribution to journalArticle

Abstract

Data in favor of the hypothesis of the common evolutionary origin of natural immunity inflammation and stress response are presented. These phenomena seem to be mediated by a common pool of molecules (POMC-derived peptides, cytokines, biogenic amines, glucocorticoids, and nitric oxide). Macrophages are able to release all the above mentioned molecules. They play a primary role in defence mechanisms. Thus, we argue that this cell can be considered the eye-witness of the common evolutionary origin of the immune and neuroendocrine systems.

Original languageEnglish
Pages (from-to)291-296
Number of pages6
JournalDomestic Animal Endocrinology
Volume15
Issue number5
DOIs
Publication statusPublished - Sep 1998

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)
  • Endocrinology

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