A new theory on the common evolutionary origin of natural immunity, inflammation and stress response: The invertebrate phagocytic immunocyte as an eye-witness

E. Ottaviani, C. Franceschi

Research output: Contribution to journalArticlepeer-review

Abstract

Data in favor of the hypothesis of the common evolutionary origin of natural immunity inflammation and stress response are presented. These phenomena seem to be mediated by a common pool of molecules (POMC-derived peptides, cytokines, biogenic amines, glucocorticoids, and nitric oxide). Macrophages are able to release all the above mentioned molecules. They play a primary role in defence mechanisms. Thus, we argue that this cell can be considered the eye-witness of the common evolutionary origin of the immune and neuroendocrine systems.

Original languageEnglish
Pages (from-to)291-296
Number of pages6
JournalDomestic Animal Endocrinology
Volume15
Issue number5
DOIs
Publication statusPublished - Sep 1998

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)
  • Endocrinology

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