A new tool to assess responsiveness in disorders of consciousness (DoC)

a preliminary study on the Brief Post-Coma Scale (BPCS)

on the behalf of the Italian National Consortium on Functioning and Disability in Disorders of Consciousness Patients

Research output: Contribution to journalArticle

Abstract

Introduction: The Brief Post-Coma Scale (BPCS) is an easy diagnostic tool for individuals with disorders of consciousness (DoC), in a reduced version from a previously Post-Coma Scale, that could distinguish patients in the minimally conscious state (MCS) from those in unresponsive wakefulness syndrome (UWS), formerly defined as vegetative state (VS). Objective: Aim of the study was to assess the diagnostic validity of the BPCS in comparison with the Coma Recovery Scale-Revised (CRS-R), in its Italian validated version, the Disability Rating Scale (DRS), the Level of Cognitive Functioning (LCF), and the Glasgow Outcome Scale (GOS). Methods: In an Italian multicenter study on 545 patients with DoC, 36 post-acute rehabilitation wards, 32 long-term care centers, and 2 family associations participated to data collection. Results: Statistically significant correlations were found between the BPCS and the other clinical scales: R = 0.586 (p < 0.001) with LCF, R = − 0.566 (p < 0.001) with DRS, R = 0.622 (p < 0.001) with CRS-R. The BPCS scores resulted significantly correlated with the time from acute event (R = 0.117, p = 0.006). Patients with GOS score 2 had mean BPCS of 1.84 ± 1.19, whereas those with GOS 3 had significantly higher scores 3.88 ± 1.71 (p < 0.001). Similarly, in patients with vegetative state/UWS (VS/UWS), the mean BPSC score was 1.71 ± 1.09, significantly lower (p < 0.001) than that of patients with minimally conscious state (BPCS = 3.83 ± 1.29). Finally, the agreement of the BPCS and clinical diagnosis was of 84.4%, with an odds ratio OR = 3.781 (95% CI = 3.026–4.725, p < 0.001). Conclusions: The BPCS has demonstrated statistically significant correlations with the most commonly used scales in persons with DoC.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalNeurological Sciences
DOIs
Publication statusAccepted/In press - Jun 15 2018

Fingerprint

Consciousness Disorders
Coma
Persistent Vegetative State
Glasgow Outcome Scale
Wakefulness
Long-Term Care
Multicenter Studies
Rehabilitation
Odds Ratio

Keywords

  • Brief Post-Coma Scale
  • Coma Recovery Scale-Revised
  • Disorders of consciousness
  • Outcome evaluation scales

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

on the behalf of the Italian National Consortium on Functioning and Disability in Disorders of Consciousness Patients (Accepted/In press). A new tool to assess responsiveness in disorders of consciousness (DoC): a preliminary study on the Brief Post-Coma Scale (BPCS). Neurological Sciences, 1-6. https://doi.org/10.1007/s10072-018-3466-3

A new tool to assess responsiveness in disorders of consciousness (DoC) : a preliminary study on the Brief Post-Coma Scale (BPCS). / on the behalf of the Italian National Consortium on Functioning and Disability in Disorders of Consciousness Patients.

In: Neurological Sciences, 15.06.2018, p. 1-6.

Research output: Contribution to journalArticle

on the behalf of the Italian National Consortium on Functioning and Disability in Disorders of Consciousness Patients 2018, 'A new tool to assess responsiveness in disorders of consciousness (DoC): a preliminary study on the Brief Post-Coma Scale (BPCS)', Neurological Sciences, pp. 1-6. https://doi.org/10.1007/s10072-018-3466-3
on the behalf of the Italian National Consortium on Functioning and Disability in Disorders of Consciousness Patients. A new tool to assess responsiveness in disorders of consciousness (DoC): a preliminary study on the Brief Post-Coma Scale (BPCS). Neurological Sciences. 2018 Jun 15;1-6. https://doi.org/10.1007/s10072-018-3466-3
on the behalf of the Italian National Consortium on Functioning and Disability in Disorders of Consciousness Patients. / A new tool to assess responsiveness in disorders of consciousness (DoC) : a preliminary study on the Brief Post-Coma Scale (BPCS). In: Neurological Sciences. 2018 ; pp. 1-6.
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abstract = "Introduction: The Brief Post-Coma Scale (BPCS) is an easy diagnostic tool for individuals with disorders of consciousness (DoC), in a reduced version from a previously Post-Coma Scale, that could distinguish patients in the minimally conscious state (MCS) from those in unresponsive wakefulness syndrome (UWS), formerly defined as vegetative state (VS). Objective: Aim of the study was to assess the diagnostic validity of the BPCS in comparison with the Coma Recovery Scale-Revised (CRS-R), in its Italian validated version, the Disability Rating Scale (DRS), the Level of Cognitive Functioning (LCF), and the Glasgow Outcome Scale (GOS). Methods: In an Italian multicenter study on 545 patients with DoC, 36 post-acute rehabilitation wards, 32 long-term care centers, and 2 family associations participated to data collection. Results: Statistically significant correlations were found between the BPCS and the other clinical scales: R = 0.586 (p < 0.001) with LCF, R = − 0.566 (p < 0.001) with DRS, R = 0.622 (p < 0.001) with CRS-R. The BPCS scores resulted significantly correlated with the time from acute event (R = 0.117, p = 0.006). Patients with GOS score 2 had mean BPCS of 1.84 ± 1.19, whereas those with GOS 3 had significantly higher scores 3.88 ± 1.71 (p < 0.001). Similarly, in patients with vegetative state/UWS (VS/UWS), the mean BPSC score was 1.71 ± 1.09, significantly lower (p < 0.001) than that of patients with minimally conscious state (BPCS = 3.83 ± 1.29). Finally, the agreement of the BPCS and clinical diagnosis was of 84.4{\%}, with an odds ratio OR = 3.781 (95{\%} CI = 3.026–4.725, p < 0.001). Conclusions: The BPCS has demonstrated statistically significant correlations with the most commonly used scales in persons with DoC.",
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author = "{on the behalf of the Italian National Consortium on Functioning and Disability in Disorders of Consciousness Patients} and Rita Formisano and Marta Aloisi and Marco Iosa and Marianna Contrada and Federica Rizza and Davide Sattin and Matilde Leonardi and Mariagrazia D’Ippolito",
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T1 - A new tool to assess responsiveness in disorders of consciousness (DoC)

T2 - a preliminary study on the Brief Post-Coma Scale (BPCS)

AU - on the behalf of the Italian National Consortium on Functioning and Disability in Disorders of Consciousness Patients

AU - Formisano, Rita

AU - Aloisi, Marta

AU - Iosa, Marco

AU - Contrada, Marianna

AU - Rizza, Federica

AU - Sattin, Davide

AU - Leonardi, Matilde

AU - D’Ippolito, Mariagrazia

PY - 2018/6/15

Y1 - 2018/6/15

N2 - Introduction: The Brief Post-Coma Scale (BPCS) is an easy diagnostic tool for individuals with disorders of consciousness (DoC), in a reduced version from a previously Post-Coma Scale, that could distinguish patients in the minimally conscious state (MCS) from those in unresponsive wakefulness syndrome (UWS), formerly defined as vegetative state (VS). Objective: Aim of the study was to assess the diagnostic validity of the BPCS in comparison with the Coma Recovery Scale-Revised (CRS-R), in its Italian validated version, the Disability Rating Scale (DRS), the Level of Cognitive Functioning (LCF), and the Glasgow Outcome Scale (GOS). Methods: In an Italian multicenter study on 545 patients with DoC, 36 post-acute rehabilitation wards, 32 long-term care centers, and 2 family associations participated to data collection. Results: Statistically significant correlations were found between the BPCS and the other clinical scales: R = 0.586 (p < 0.001) with LCF, R = − 0.566 (p < 0.001) with DRS, R = 0.622 (p < 0.001) with CRS-R. The BPCS scores resulted significantly correlated with the time from acute event (R = 0.117, p = 0.006). Patients with GOS score 2 had mean BPCS of 1.84 ± 1.19, whereas those with GOS 3 had significantly higher scores 3.88 ± 1.71 (p < 0.001). Similarly, in patients with vegetative state/UWS (VS/UWS), the mean BPSC score was 1.71 ± 1.09, significantly lower (p < 0.001) than that of patients with minimally conscious state (BPCS = 3.83 ± 1.29). Finally, the agreement of the BPCS and clinical diagnosis was of 84.4%, with an odds ratio OR = 3.781 (95% CI = 3.026–4.725, p < 0.001). Conclusions: The BPCS has demonstrated statistically significant correlations with the most commonly used scales in persons with DoC.

AB - Introduction: The Brief Post-Coma Scale (BPCS) is an easy diagnostic tool for individuals with disorders of consciousness (DoC), in a reduced version from a previously Post-Coma Scale, that could distinguish patients in the minimally conscious state (MCS) from those in unresponsive wakefulness syndrome (UWS), formerly defined as vegetative state (VS). Objective: Aim of the study was to assess the diagnostic validity of the BPCS in comparison with the Coma Recovery Scale-Revised (CRS-R), in its Italian validated version, the Disability Rating Scale (DRS), the Level of Cognitive Functioning (LCF), and the Glasgow Outcome Scale (GOS). Methods: In an Italian multicenter study on 545 patients with DoC, 36 post-acute rehabilitation wards, 32 long-term care centers, and 2 family associations participated to data collection. Results: Statistically significant correlations were found between the BPCS and the other clinical scales: R = 0.586 (p < 0.001) with LCF, R = − 0.566 (p < 0.001) with DRS, R = 0.622 (p < 0.001) with CRS-R. The BPCS scores resulted significantly correlated with the time from acute event (R = 0.117, p = 0.006). Patients with GOS score 2 had mean BPCS of 1.84 ± 1.19, whereas those with GOS 3 had significantly higher scores 3.88 ± 1.71 (p < 0.001). Similarly, in patients with vegetative state/UWS (VS/UWS), the mean BPSC score was 1.71 ± 1.09, significantly lower (p < 0.001) than that of patients with minimally conscious state (BPCS = 3.83 ± 1.29). Finally, the agreement of the BPCS and clinical diagnosis was of 84.4%, with an odds ratio OR = 3.781 (95% CI = 3.026–4.725, p < 0.001). Conclusions: The BPCS has demonstrated statistically significant correlations with the most commonly used scales in persons with DoC.

KW - Brief Post-Coma Scale

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KW - Outcome evaluation scales

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