A new treatment regimen with permethrin in scabies

Stefano Veraldi, Paolo De Micheli, Rossana Schianchi, Paolo Pontini

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Topical permethrin, applied once daily, is considered as the most effective treatment in scabies. METHODS: Eighty-nine adult immunocompetent patients with scabies were treated with 5% permethrin cream: 42 patients were treated with a single application/day (group 1); 47 patients were treated with one application/day for two consecutive days (group 2). Clinical diagnosis of scabies was confirmed by microscopical examinations. The cream was stored in refrigerator and applied cold on the entire skin surface. The cream was left on the skin for 24 hours. No other topical or systemic drugs were allowed, except for a cleanser with chlorhexidine. The treatment was repeated in all patients 7-10 days later. The follow-up was 2 months after the end of the treatment. RESULT S: Twenty-one patients (61.8%) in the group 1 and 34 patients (87.2%) in the group 2 were considered recovered both clinically and microscopically. Three patients (7.1%) in the group 1 and 4 patients (10.2%) in the group 2 developed a mild irritant contact dermatitis. During follow-up, three patients (7.1%) in the group 1 and two patients (4.2%) in the group 2 developed a recurrence or a re-infestation. CONCLUSIONS: Five per cent permethrin, when applied as cold cream, on the entire skin surface, once daily for two consecutive days, is more effective than the single application in adult immunocompetent patients with scabies.

Original languageEnglish
Pages (from-to)491-493
Number of pages3
JournalGiornale Italiano di Dermatologia e Venereologia
Issue number4
Publication statusPublished - Aug 1 2018


  • Permethrin
  • Scabies
  • Skin cream

ASJC Scopus subject areas

  • Dermatology


Dive into the research topics of 'A new treatment regimen with permethrin in scabies'. Together they form a unique fingerprint.

Cite this