A new treatment regimen with permethrin in scabies

Stefano Veraldi, Paolo De Micheli, Rossana Schianchi, Paolo Pontini

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

BACKGROUND: Topical permethrin, applied once daily, is considered as the most effective treatment in scabies. METHODS: Eighty-nine adult immunocompetent patients with scabies were treated with 5% permethrin cream: 42 patients were treated with a single application/day (group 1); 47 patients were treated with one application/day for two consecutive days (group 2). Clinical diagnosis of scabies was confirmed by microscopical examinations. The cream was stored in refrigerator and applied cold on the entire skin surface. The cream was left on the skin for 24 hours. No other topical or systemic drugs were allowed, except for a cleanser with chlorhexidine. The treatment was repeated in all patients 7-10 days later. The follow-up was 2 months after the end of the treatment. RESULT S: Twenty-one patients (61.8%) in the group 1 and 34 patients (87.2%) in the group 2 were considered recovered both clinically and microscopically. Three patients (7.1%) in the group 1 and 4 patients (10.2%) in the group 2 developed a mild irritant contact dermatitis. During follow-up, three patients (7.1%) in the group 1 and two patients (4.2%) in the group 2 developed a recurrence or a re-infestation. CONCLUSIONS: Five per cent permethrin, when applied as cold cream, on the entire skin surface, once daily for two consecutive days, is more effective than the single application in adult immunocompetent patients with scabies.

Original languageEnglish
Pages (from-to)491-493
Number of pages3
JournalGiornale Italiano di Dermatologia e Venereologia
Volume153
Issue number4
DOIs
Publication statusPublished - Aug 1 2018

Fingerprint

Permethrin
Scabies
Therapeutics
Skin
Irritant Dermatitis
Chlorhexidine
Contact Dermatitis

Keywords

  • Permethrin
  • Scabies
  • Skin cream

ASJC Scopus subject areas

  • Dermatology

Cite this

A new treatment regimen with permethrin in scabies. / Veraldi, Stefano; De Micheli, Paolo; Schianchi, Rossana; Pontini, Paolo.

In: Giornale Italiano di Dermatologia e Venereologia, Vol. 153, No. 4, 01.08.2018, p. 491-493.

Research output: Contribution to journalArticle

Veraldi, Stefano ; De Micheli, Paolo ; Schianchi, Rossana ; Pontini, Paolo. / A new treatment regimen with permethrin in scabies. In: Giornale Italiano di Dermatologia e Venereologia. 2018 ; Vol. 153, No. 4. pp. 491-493.
@article{dc3f387cc0344ce783b08bd6c412a208,
title = "A new treatment regimen with permethrin in scabies",
abstract = "BACKGROUND: Topical permethrin, applied once daily, is considered as the most effective treatment in scabies. METHODS: Eighty-nine adult immunocompetent patients with scabies were treated with 5{\%} permethrin cream: 42 patients were treated with a single application/day (group 1); 47 patients were treated with one application/day for two consecutive days (group 2). Clinical diagnosis of scabies was confirmed by microscopical examinations. The cream was stored in refrigerator and applied cold on the entire skin surface. The cream was left on the skin for 24 hours. No other topical or systemic drugs were allowed, except for a cleanser with chlorhexidine. The treatment was repeated in all patients 7-10 days later. The follow-up was 2 months after the end of the treatment. RESULT S: Twenty-one patients (61.8{\%}) in the group 1 and 34 patients (87.2{\%}) in the group 2 were considered recovered both clinically and microscopically. Three patients (7.1{\%}) in the group 1 and 4 patients (10.2{\%}) in the group 2 developed a mild irritant contact dermatitis. During follow-up, three patients (7.1{\%}) in the group 1 and two patients (4.2{\%}) in the group 2 developed a recurrence or a re-infestation. CONCLUSIONS: Five per cent permethrin, when applied as cold cream, on the entire skin surface, once daily for two consecutive days, is more effective than the single application in adult immunocompetent patients with scabies.",
keywords = "Permethrin, Scabies, Skin cream",
author = "Stefano Veraldi and {De Micheli}, Paolo and Rossana Schianchi and Paolo Pontini",
year = "2018",
month = "8",
day = "1",
doi = "10.23736/S0392-0488.16.05404-3",
language = "English",
volume = "153",
pages = "491--493",
journal = "Minerva dermatologica",
issn = "0392-0488",
publisher = "Edizioni Minerva Medica S.p.A.",
number = "4",

}

TY - JOUR

T1 - A new treatment regimen with permethrin in scabies

AU - Veraldi, Stefano

AU - De Micheli, Paolo

AU - Schianchi, Rossana

AU - Pontini, Paolo

PY - 2018/8/1

Y1 - 2018/8/1

N2 - BACKGROUND: Topical permethrin, applied once daily, is considered as the most effective treatment in scabies. METHODS: Eighty-nine adult immunocompetent patients with scabies were treated with 5% permethrin cream: 42 patients were treated with a single application/day (group 1); 47 patients were treated with one application/day for two consecutive days (group 2). Clinical diagnosis of scabies was confirmed by microscopical examinations. The cream was stored in refrigerator and applied cold on the entire skin surface. The cream was left on the skin for 24 hours. No other topical or systemic drugs were allowed, except for a cleanser with chlorhexidine. The treatment was repeated in all patients 7-10 days later. The follow-up was 2 months after the end of the treatment. RESULT S: Twenty-one patients (61.8%) in the group 1 and 34 patients (87.2%) in the group 2 were considered recovered both clinically and microscopically. Three patients (7.1%) in the group 1 and 4 patients (10.2%) in the group 2 developed a mild irritant contact dermatitis. During follow-up, three patients (7.1%) in the group 1 and two patients (4.2%) in the group 2 developed a recurrence or a re-infestation. CONCLUSIONS: Five per cent permethrin, when applied as cold cream, on the entire skin surface, once daily for two consecutive days, is more effective than the single application in adult immunocompetent patients with scabies.

AB - BACKGROUND: Topical permethrin, applied once daily, is considered as the most effective treatment in scabies. METHODS: Eighty-nine adult immunocompetent patients with scabies were treated with 5% permethrin cream: 42 patients were treated with a single application/day (group 1); 47 patients were treated with one application/day for two consecutive days (group 2). Clinical diagnosis of scabies was confirmed by microscopical examinations. The cream was stored in refrigerator and applied cold on the entire skin surface. The cream was left on the skin for 24 hours. No other topical or systemic drugs were allowed, except for a cleanser with chlorhexidine. The treatment was repeated in all patients 7-10 days later. The follow-up was 2 months after the end of the treatment. RESULT S: Twenty-one patients (61.8%) in the group 1 and 34 patients (87.2%) in the group 2 were considered recovered both clinically and microscopically. Three patients (7.1%) in the group 1 and 4 patients (10.2%) in the group 2 developed a mild irritant contact dermatitis. During follow-up, three patients (7.1%) in the group 1 and two patients (4.2%) in the group 2 developed a recurrence or a re-infestation. CONCLUSIONS: Five per cent permethrin, when applied as cold cream, on the entire skin surface, once daily for two consecutive days, is more effective than the single application in adult immunocompetent patients with scabies.

KW - Permethrin

KW - Scabies

KW - Skin cream

UR - http://www.scopus.com/inward/record.url?scp=85048216926&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048216926&partnerID=8YFLogxK

U2 - 10.23736/S0392-0488.16.05404-3

DO - 10.23736/S0392-0488.16.05404-3

M3 - Article

AN - SCOPUS:85048216926

VL - 153

SP - 491

EP - 493

JO - Minerva dermatologica

JF - Minerva dermatologica

SN - 0392-0488

IS - 4

ER -