A newer perspective in the surgical approach to endometrial cancer: Sentinel lymph node evaluation

Giulio Evangelisti, Fabio Barra, Simone Ferrero

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In recent years sentinel lymph node mapping has emerged as an attractive approach for the treatment of endometrial cancer (EC). Its feasibility in early-stage disease has been confirmed by several studies, although it is not clear which is the best mapping technique and injection site of tracer. Recent studies have shown that a radical lymphadenectomy (LND) may have no therapeutic benefit in patients with early-stage EC; subsequently, SLN mapping may decrease lymph node dissections where unnecessary. The recent introduction of ultrastaging in the pathological evaluation of lymph nodes has improved the rate detection of low volume metastases but the prognostic significance of these findings is still unclear, and the optimal postsurgical management for these patients has not yet been identified. This chapter, through the analysis of available literature, provide an update on the role of sentinel lymph node evaluation in EC.

Original languageEnglish
Title of host publicationEndometrial Cancer
Subtitle of host publicationRisk Factors, Management and Prognosis
PublisherNova Science Publishers, Inc.
Pages209-230
Number of pages22
ISBN (Electronic)9781536138887
ISBN (Print)9781536138870
Publication statusPublished - Jan 1 2018

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Keywords

  • Endometrial cancer
  • Low volume metastases
  • Lymph node biopsy
  • Mapping techniques
  • Sentinel lymph node
  • Ultrastaging

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Evangelisti, G., Barra, F., & Ferrero, S. (2018). A newer perspective in the surgical approach to endometrial cancer: Sentinel lymph node evaluation. In Endometrial Cancer: Risk Factors, Management and Prognosis (pp. 209-230). Nova Science Publishers, Inc..