Abstract
Objectives: To report the association between thoracic vascular malformations observed in the first trimester of pregnancy and Down syndrome. Methods: The clinical features were reviewed of seven fetuses undergoing chorionic villus sampling (CVS) for increased nuchal translucency (NT) thickness, in which color Doppler ultrasonography revealed a vascular malformation in the fetal thorax. Results: The crown-rump length of the fetuses ranged from 58 to 78 mm and NT measurements ranged from 2.9 to 10.0 mm. Color Doppler allowed the identification of a highly vascular structure in the posterolateral portion of the fetal thorax, in proximity to the costovertebral angle, at the level of a four-chamber view of the heart. The lesions had a globular shape and were 4-6 mm in diameter, occupying almost one third of the hemithorax. Down syndrome was diagnosed in five out of the seven cases. In the only affected case that underwent postmortem examination, a hemangioma of the chest wall was demonstrated. In the two fetuses with normal karyotype, the lesion disappeared by mid-gestation. Conclusion: We report an association between the prenatal Doppler finding of a vascular tumor in the fetal chest and Down syndrome.
| Original language | English |
|---|---|
| Pages (from-to) | 218-220 |
| Number of pages | 3 |
| Journal | Ultrasound in Obstetrics and Gynecology |
| Volume | 26 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 2005 |
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Keywords
- Color Doppler
- Down syndrome
- First trimester
- Hemangioma
- Nuchal translucency
ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
- Reproductive Medicine
- Acoustics and Ultrasonics
Cite this
A newly described thoracic vascular malformation in fetuses with Down syndrome. / Prefumo, F.; Ierullo, A. M.; Fulcheri, E.; Venturini, P. L.; De Biasio, P.; Thilaganathan, B.
In: Ultrasound in Obstetrics and Gynecology, Vol. 26, No. 3, 09.2005, p. 218-220.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A newly described thoracic vascular malformation in fetuses with Down syndrome
AU - Prefumo, F.
AU - Ierullo, A. M.
AU - Fulcheri, E.
AU - Venturini, P. L.
AU - De Biasio, P.
AU - Thilaganathan, B.
PY - 2005/9
Y1 - 2005/9
N2 - Objectives: To report the association between thoracic vascular malformations observed in the first trimester of pregnancy and Down syndrome. Methods: The clinical features were reviewed of seven fetuses undergoing chorionic villus sampling (CVS) for increased nuchal translucency (NT) thickness, in which color Doppler ultrasonography revealed a vascular malformation in the fetal thorax. Results: The crown-rump length of the fetuses ranged from 58 to 78 mm and NT measurements ranged from 2.9 to 10.0 mm. Color Doppler allowed the identification of a highly vascular structure in the posterolateral portion of the fetal thorax, in proximity to the costovertebral angle, at the level of a four-chamber view of the heart. The lesions had a globular shape and were 4-6 mm in diameter, occupying almost one third of the hemithorax. Down syndrome was diagnosed in five out of the seven cases. In the only affected case that underwent postmortem examination, a hemangioma of the chest wall was demonstrated. In the two fetuses with normal karyotype, the lesion disappeared by mid-gestation. Conclusion: We report an association between the prenatal Doppler finding of a vascular tumor in the fetal chest and Down syndrome.
AB - Objectives: To report the association between thoracic vascular malformations observed in the first trimester of pregnancy and Down syndrome. Methods: The clinical features were reviewed of seven fetuses undergoing chorionic villus sampling (CVS) for increased nuchal translucency (NT) thickness, in which color Doppler ultrasonography revealed a vascular malformation in the fetal thorax. Results: The crown-rump length of the fetuses ranged from 58 to 78 mm and NT measurements ranged from 2.9 to 10.0 mm. Color Doppler allowed the identification of a highly vascular structure in the posterolateral portion of the fetal thorax, in proximity to the costovertebral angle, at the level of a four-chamber view of the heart. The lesions had a globular shape and were 4-6 mm in diameter, occupying almost one third of the hemithorax. Down syndrome was diagnosed in five out of the seven cases. In the only affected case that underwent postmortem examination, a hemangioma of the chest wall was demonstrated. In the two fetuses with normal karyotype, the lesion disappeared by mid-gestation. Conclusion: We report an association between the prenatal Doppler finding of a vascular tumor in the fetal chest and Down syndrome.
KW - Color Doppler
KW - Down syndrome
KW - First trimester
KW - Hemangioma
KW - Nuchal translucency
UR - http://www.scopus.com/inward/record.url?scp=27544489895&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27544489895&partnerID=8YFLogxK
U2 - 10.1002/uog.1979
DO - 10.1002/uog.1979
M3 - Article
C2 - 16094677
AN - SCOPUS:27544489895
VL - 26
SP - 218
EP - 220
JO - Ultrasound in Obstetrics and Gynecology
JF - Ultrasound in Obstetrics and Gynecology
SN - 0960-7692
IS - 3
ER -