A nine‐gene signature for predicting the response to preoperative chemoradiotherapy in patients with locally advanced rectal cancer

In Ja Park, Yun Suk Yu, Bilal Mustafa, Jin Young Park, Yong Bae Seo, Gun Do Kim, Jinpyo Kim, Chang Min Kim, Hyun Deok Noh, Seung Mo Hong, Yeon Wook Kim, Mi Ju Kim, Adnan Ahmad Ansari, Luigi Buonaguro, Sung Min Ahn, Chang Sik Yu

Research output: Contribution to journalArticlepeer-review

Abstract

Preoperative chemoradiotherapy (PCRT) and subsequent surgery is the standard multimodal treatment for locally advanced rectal cancer (LARC), albeit PCRT response varies among the individuals. This creates a dire necessity to identify a predictive model to forecast treatment response outcomes and identify patients who would benefit from PCRT. In this study, we performed a gene expression study using formalin‐fixed paraffin‐embedded (FFPE) tumor biopsy samples from 156 LARC patients (training cohort n = 60; validation cohort n = 96); we identified the nine‐gene signature (FGFR3, GNA11, H3F3A, IL12A, IL1R1, IL2RB, NKD1, SGK2, and SPRY2) that distinctively differentiated responders from non‐responders in the training cohort (accuracy = 86.9%, specificity = 84.8%, sensitivity = 81.5%) as well as in an independent validation cohort (accuracy = 81.0%, specificity = 79.4%, sensitivity = 82.3%). The signature was independent of all pathological and clinical features and was robust in predicting PCRT response. It is readily applicable to the clinical setting using FFPE samples and Food and Drug Administration (FDA) approved hardware and reagents. Predicting the response to PCRT may aid in tailored therapies for respective responders to PCRT and improve the oncologic outcomes for LARC patients.

Original languageEnglish
Article number800
JournalCancers
Volume12
Issue number4
DOIs
Publication statusPublished - Apr 2020

Keywords

  • Biomarker
  • Locally advanced rectal cancer
  • NanoString analysis
  • Preoperative chemoradiotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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