A non invasive estimate of dead space ventilation from exercise measurements

Paola Gargiulo, Anna Apostolo, Pasquale Perrone-Filardi, Susanna Sciomer, Paolo Palange, Piergiuseppe Agostoni

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Rationale: During exercise, heart failure patients (HF) show an out-of-proportion ventilation increase, which in patients with COPD is blunted. When HF and COPD coexist, the ventilatory response to exercise is unpredictable. Objectives: We evaluated a human model of respiratory impairment in 10 COPD-free HF patients and in 10 healthy subjects, tested with a progressive workload exercise with different added dead space. We hypothesized that increased serial dead space upshifts the VE vs. VCO2 relationship and that the VE-axis intercept might be an index of dead space ventilation. Measurements: All participants performed a cardiopulmonary exercise test with 0, 250 and 500 mL of additional dead space. Since DS does not contribute to gas exchange, ventilation relative to dead space is ventilation at VCO2 = 0, i.e. VE-axis intercept. We compared dead space volume, estimated dividing VE-axis intercept by the intercept on respiratory rate axis of the respiratory rate vs. VCO2 relationship with standard method measured DS. Main results: In HF, adding dead space increased VE-axis intercept (+0 mL = 4.98±1.63 L; +250 mL = 9.69±2.91 L; +500 mL = 13.26±3.18 L; p2 relationship, with a minor slope rise (+0 mL= 27±4 L; +250 = 28±5; +500 = 29±4; p

Original languageEnglish
Article numbere87395
JournalPLoS One
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 30 2014

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Ventilation
exercise
heart failure
Exercise
Heart Failure
Chronic Obstructive Pulmonary Disease
Respiratory Rate
respiratory rate
pulmonary gas exchange
exercise test
Gases
Workload
Exercise Test
breathing
Healthy Volunteers

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

A non invasive estimate of dead space ventilation from exercise measurements. / Gargiulo, Paola; Apostolo, Anna; Perrone-Filardi, Pasquale; Sciomer, Susanna; Palange, Paolo; Agostoni, Piergiuseppe.

In: PLoS One, Vol. 9, No. 1, e87395, 30.01.2014.

Research output: Contribution to journalArticle

Gargiulo, Paola ; Apostolo, Anna ; Perrone-Filardi, Pasquale ; Sciomer, Susanna ; Palange, Paolo ; Agostoni, Piergiuseppe. / A non invasive estimate of dead space ventilation from exercise measurements. In: PLoS One. 2014 ; Vol. 9, No. 1.
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