A non invasive estimate of dead space ventilation from exercise measurements

Paola Gargiulo, Anna Apostolo, Pasquale Perrone-Filardi, Susanna Sciomer, Paolo Palange, Piergiuseppe Agostoni

Research output: Contribution to journalArticlepeer-review


Rationale: During exercise, heart failure patients (HF) show an out-of-proportion ventilation increase, which in patients with COPD is blunted. When HF and COPD coexist, the ventilatory response to exercise is unpredictable. Objectives: We evaluated a human model of respiratory impairment in 10 COPD-free HF patients and in 10 healthy subjects, tested with a progressive workload exercise with different added dead space. We hypothesized that increased serial dead space upshifts the VE vs. VCO2 relationship and that the VE-axis intercept might be an index of dead space ventilation. Measurements: All participants performed a cardiopulmonary exercise test with 0, 250 and 500 mL of additional dead space. Since DS does not contribute to gas exchange, ventilation relative to dead space is ventilation at VCO2 = 0, i.e. VE-axis intercept. We compared dead space volume, estimated dividing VE-axis intercept by the intercept on respiratory rate axis of the respiratory rate vs. VCO2 relationship with standard method measured DS. Main results: In HF, adding dead space increased VE-axis intercept (+0 mL = 4.98±1.63 L; +250 mL = 9.69±2.91 L; +500 mL = 13.26±3.18 L; p2 relationship, with a minor slope rise (+0 mL= 27±4 L; +250 = 28±5; +500 = 29±4; p

Original languageEnglish
Article numbere87395
JournalPLoS One
Issue number1
Publication statusPublished - Jan 30 2014

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


Dive into the research topics of 'A non invasive estimate of dead space ventilation from exercise measurements'. Together they form a unique fingerprint.

Cite this