Radioimmunological techniques were employed to measure plasma levels of FSH, LH, 17 β oestradiol and progesterone before and after surgical castration in fifteen patients. All women had regular menstrual cycles and normal gonadotrophin, 17 β oestradiol and progesterone values. After surgery, LH and FSH rose steadily to reach a peak on about the twentieth day in the case of FSH: 97 mIU/ml ± 11 S.D., and on about the 30th day in the case of LH 104 mIU/ml ± 21 S.D. By contrast, 17 β oestradiol and progesterone fell rapidly to very low values. All patients were then treated with Zeranol ( a μ lactone of β resorcilic acid) in a dose of 75 mg/die per os. Gonadotrophin levels fell rapidly, FSH more significantly than LH. In addition, to demonstrate the action of Zeranol at hypophyseal level, a stimulation test with 100 μg of synthetic GN RH was carried out before castration, 30 days afterwards, and following the first cycle of substitutive therapy. Hypophyseal response reached a peak after the operation and was reduced considerably by treatment. Metabolic control was carried out at the same time as hormone measurements, with an evaluation of plasma levels of cholesterol, NEFA and total lipides. Cholesterol and NEFA presented a rapid increase and reached their peaks about a month after ovariectomy whereas total lipides behaved in a similar fashion but with less marked variations. Therapy with lactone of resorcilic acid led to a rapid decrease in cholesterolaemia and NEFA. Zeranol would thus appear to act peripherally and at the level of the hypothalamic and hypophyseal receptors in the same way as steroid oestrogens, for which it may be a useful alternative.
|Translated title of the contribution||A non steroidal estrogen for treatment of surgically castrated women: hormonal and metabolic effects|
|Number of pages||8|
|Publication status||Published - 1976|
ASJC Scopus subject areas
- Obstetrics and Gynaecology