A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics

J. A. Cornejo-García, A. Romano, R. M. Guéant-Rodríguez, A. Oussalah, N. Blanca-López, F. Gaeta, D. Tramoy, T. Josse, I. Doña, M. J. Torres, G. Canto, M. Blanca, J. L. Guéant

Research output: Contribution to journalArticlepeer-review

Abstract

Genetic predictors of beta-lactam (BL) allergy are mostly related to Immunoglobulin E (IgE) synthesis and atopy. Despite this context, little attention has been devoted to genes of IgE/FcεRI pathway, such as galectin-3, a β-galactoside-binding lectin, which binds to IgE. We evaluated the association of LGALS3 polymorphisms with BL allergy in 395 Spanish and 198 Italian cases, compared with 310- and 339-matched controls, respectively. The rs11125 predicted BL allergy with an odds ratio of 4.0 in Spanish population (PHis substitution produced by rs11125 on galactose-binding activity of galectin-3. In conclusion, LGALS3 is the strongest genetic predictor of BL allergy reported so far. This association reflects the influence of genes of IgE/FcεRI pathway in this pathology.

Original languageEnglish
Pages (from-to)79-82
Number of pages4
JournalPharmacogenomics Journal
Volume16
Issue number1
DOIs
Publication statusPublished - Feb 1 2016

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine
  • Genetics

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