TY - JOUR
T1 - A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics
AU - Cornejo-García, J. A.
AU - Romano, A.
AU - Guéant-Rodríguez, R. M.
AU - Oussalah, A.
AU - Blanca-López, N.
AU - Gaeta, F.
AU - Tramoy, D.
AU - Josse, T.
AU - Doña, I.
AU - Torres, M. J.
AU - Canto, G.
AU - Blanca, M.
AU - Guéant, J. L.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Genetic predictors of beta-lactam (BL) allergy are mostly related to Immunoglobulin E (IgE) synthesis and atopy. Despite this context, little attention has been devoted to genes of IgE/FcεRI pathway, such as galectin-3, a β-galactoside-binding lectin, which binds to IgE. We evaluated the association of LGALS3 polymorphisms with BL allergy in 395 Spanish and 198 Italian cases, compared with 310- and 339-matched controls, respectively. The rs11125 predicted BL allergy with an odds ratio of 4.0 in Spanish population (PHis substitution produced by rs11125 on galactose-binding activity of galectin-3. In conclusion, LGALS3 is the strongest genetic predictor of BL allergy reported so far. This association reflects the influence of genes of IgE/FcεRI pathway in this pathology.
AB - Genetic predictors of beta-lactam (BL) allergy are mostly related to Immunoglobulin E (IgE) synthesis and atopy. Despite this context, little attention has been devoted to genes of IgE/FcεRI pathway, such as galectin-3, a β-galactoside-binding lectin, which binds to IgE. We evaluated the association of LGALS3 polymorphisms with BL allergy in 395 Spanish and 198 Italian cases, compared with 310- and 339-matched controls, respectively. The rs11125 predicted BL allergy with an odds ratio of 4.0 in Spanish population (PHis substitution produced by rs11125 on galactose-binding activity of galectin-3. In conclusion, LGALS3 is the strongest genetic predictor of BL allergy reported so far. This association reflects the influence of genes of IgE/FcεRI pathway in this pathology.
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U2 - 10.1038/tpj.2015.24
DO - 10.1038/tpj.2015.24
M3 - Article
C2 - 25869013
AN - SCOPUS:84956745407
VL - 16
SP - 79
EP - 82
JO - Pharmacogenomics Journal
JF - Pharmacogenomics Journal
SN - 1470-269X
IS - 1
ER -