A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics

J. A. Cornejo-García; A. Romano; R. M. Guéant-Rodríguez; A. Oussalah; N. Blanca-López; F. Gaeta; D. Tramoy; T. Josse; I. Doña; M. J. Torres; G. Canto; M. Blanca; J. L. Guéant

doi:10.1038/tpj.2015.24

A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics

J. A. Cornejo-García, A. Romano, R. M. Guéant-Rodríguez, A. Oussalah, N. Blanca-López, F. Gaeta, D. Tramoy, T. Josse, I. Doña, M. J. Torres, G. Canto, M. Blanca, J. L. Guéant

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Abstract

Genetic predictors of beta-lactam (BL) allergy are mostly related to Immunoglobulin E (IgE) synthesis and atopy. Despite this context, little attention has been devoted to genes of IgE/FcεRI pathway, such as galectin-3, a β-galactoside-binding lectin, which binds to IgE. We evaluated the association of LGALS3 polymorphisms with BL allergy in 395 Spanish and 198 Italian cases, compared with 310- and 339-matched controls, respectively. The rs11125 predicted BL allergy with an odds ratio of 4.0 in Spanish population (PHis substitution produced by rs11125 on galactose-binding activity of galectin-3. In conclusion, LGALS3 is the strongest genetic predictor of BL allergy reported so far. This association reflects the influence of genes of IgE/FcεRI pathway in this pathology.

Original language	English
Pages (from-to)	79-82
Number of pages	4
Journal	Pharmacogenomics Journal
Volume	16
Issue number	1
DOIs	https://doi.org/10.1038/tpj.2015.24
Publication status	Published - Feb 1 2016

ASJC Scopus subject areas

Pharmacology
Molecular Medicine
Genetics

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Cornejo-García, J. A., Romano, A., Guéant-Rodríguez, R. M., Oussalah, A., Blanca-López, N., Gaeta, F., Tramoy, D., Josse, T., Doña, I., Torres, M. J., Canto, G., Blanca, M., & Guéant, J. L. (2016). A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics. Pharmacogenomics Journal, 16(1), 79-82. https://doi.org/10.1038/tpj.2015.24

A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics. / Cornejo-García, J. A.; Romano, A.; Guéant-Rodríguez, R. M.; Oussalah, A.; Blanca-López, N.; Gaeta, F.; Tramoy, D.; Josse, T.; Doña, I.; Torres, M. J.; Canto, G.; Blanca, M.; Guéant, J. L.

In: Pharmacogenomics Journal, Vol. 16, No. 1, 01.02.2016, p. 79-82.

Research output: Contribution to journal › Article › peer-review

Cornejo-García, JA, Romano, A, Guéant-Rodríguez, RM, Oussalah, A, Blanca-López, N, Gaeta, F, Tramoy, D, Josse, T, Doña, I, Torres, MJ, Canto, G, Blanca, M & Guéant, JL 2016, 'A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics', Pharmacogenomics Journal, vol. 16, no. 1, pp. 79-82. https://doi.org/10.1038/tpj.2015.24

Cornejo-García, J. A. ; Romano, A. ; Guéant-Rodríguez, R. M. ; Oussalah, A. ; Blanca-López, N. ; Gaeta, F. ; Tramoy, D. ; Josse, T. ; Doña, I. ; Torres, M. J. ; Canto, G. ; Blanca, M. ; Guéant, J. L. / A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics. In: Pharmacogenomics Journal. 2016 ; Vol. 16, No. 1. pp. 79-82.

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abstract = "Genetic predictors of beta-lactam (BL) allergy are mostly related to Immunoglobulin E (IgE) synthesis and atopy. Despite this context, little attention has been devoted to genes of IgE/FcεRI pathway, such as galectin-3, a β-galactoside-binding lectin, which binds to IgE. We evaluated the association of LGALS3 polymorphisms with BL allergy in 395 Spanish and 198 Italian cases, compared with 310- and 339-matched controls, respectively. The rs11125 predicted BL allergy with an odds ratio of 4.0 in Spanish population (PHis substitution produced by rs11125 on galactose-binding activity of galectin-3. In conclusion, LGALS3 is the strongest genetic predictor of BL allergy reported so far. This association reflects the influence of genes of IgE/FcεRI pathway in this pathology.",

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AU - Oussalah, A.

AU - Blanca-López, N.

AU - Gaeta, F.

AU - Tramoy, D.

AU - Josse, T.

AU - Doña, I.

AU - Torres, M. J.

AU - Canto, G.

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A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics

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