TY - JOUR
T1 - A noradrenergic component of quinolinic acid-induced seizures
AU - Vezzani, Annamaria
AU - Schwarcz, Robert
PY - 1985
Y1 - 1985
N2 - Unilateral application of the convulsant brain metabolite, quinolinic acid, to unanesthetized rats resulted in a transient dramatic decrease in norepinephrine levels (nadir-70% after 2 h) in both the injected and the contralateral hippocampus. Dose-response relationships and the temporal sequence of this effect indicated a close functional association between seizure events and the decrease in hippocampal norepinephrine content. Massive release of the inhibitory transmitter, norepinephrine, may thus constitute the brain's defensive response to quinolinic acid-induced seizures.
AB - Unilateral application of the convulsant brain metabolite, quinolinic acid, to unanesthetized rats resulted in a transient dramatic decrease in norepinephrine levels (nadir-70% after 2 h) in both the injected and the contralateral hippocampus. Dose-response relationships and the temporal sequence of this effect indicated a close functional association between seizure events and the decrease in hippocampal norepinephrine content. Massive release of the inhibitory transmitter, norepinephrine, may thus constitute the brain's defensive response to quinolinic acid-induced seizures.
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U2 - 10.1016/0014-4886(85)90057-3
DO - 10.1016/0014-4886(85)90057-3
M3 - Article
C2 - 2931301
AN - SCOPUS:0022411194
VL - 90
SP - 254
EP - 258
JO - Experimental Neurology
JF - Experimental Neurology
SN - 0014-4886
IS - 1
ER -