A noradrenergic component of quinolinic acid-induced seizures

Annamaria Vezzani, Robert Schwarcz

Research output: Contribution to journalArticlepeer-review

Abstract

Unilateral application of the convulsant brain metabolite, quinolinic acid, to unanesthetized rats resulted in a transient dramatic decrease in norepinephrine levels (nadir-70% after 2 h) in both the injected and the contralateral hippocampus. Dose-response relationships and the temporal sequence of this effect indicated a close functional association between seizure events and the decrease in hippocampal norepinephrine content. Massive release of the inhibitory transmitter, norepinephrine, may thus constitute the brain's defensive response to quinolinic acid-induced seizures.

Original languageEnglish
Pages (from-to)254-258
Number of pages5
JournalExperimental Neurology
Volume90
Issue number1
DOIs
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology

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