A nosocomial outbreak of invasive listeriosis in an italian hospital: Epidemiological and genomic features

Valeria Russini, Martina Spaziante, Tiziana Zottola, Anna Giovanna Fermani, Gina Di Giampietro, Giovanni Blanco, Paolo Fabietti, Riccardo Marrone, Roberta Parisella, Sergio Parrocchia, Teresa Bossù, Stefano Bilei, Maria Laura De Marchis

Research output: Contribution to journalArticlepeer-review

Abstract

Listeria monocytogenes (L. monocytogenes) is a widespread opportunistic pathogen that causes the listeriosis foodborne disease. This bacterium has become a common contaminant of handled food, and a relevant public health issue. Here we describe a nosocomial outbreak of listeriosis caused by an ST451 strain of L. monocytogenes involving three cancer and one immunocompromised patients hospitalized in different units from the same hospital during September and October 2020. The epidemiological investigation was conducted using traditional microbiological methodology combined with a whole genome sequencing approach. The source of contamination was identified in the kitchen hospital, where a meat slicer used to prepare patients’ meals was tested positive to the same sequence type (ST) of L. monocytogenes. This is the first report of an outbreak of listeriosis caused by ST451 in Italy.

Original languageEnglish
Article number591
Pages (from-to)1-12
Number of pages12
JournalPathogens
Volume10
Issue number5
DOIs
Publication statusPublished - 2021

Keywords

  • Listeria monocytogenes
  • Listeriosis
  • Nosocomial outbreak
  • ST451
  • Whole genome sequencing

ASJC Scopus subject areas

  • Immunology and Allergy
  • Molecular Biology
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'A nosocomial outbreak of invasive listeriosis in an italian hospital: Epidemiological and genomic features'. Together they form a unique fingerprint.

Cite this