A novel approach of fMRI-guided tractography analysis within a group: Construction of an fMRI-guided tractographic atlas

Maria Giulia Preti, Nikos Makris, Maria Marcella Lagana, George Papadimitriou, Francesca Baglio, Ludovica Griffanti, Raffaello Nemni, Pietro Cecconi, Carl Fredrik Westin, Giuseppe Baselli

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Diffusion Tensor Imaging (DTI) tractography and functional Magnetic Resonance Imaging (fMRI) investigate two complementary aspects of brain networks: white matter (WM) anatomical connectivity and gray matter (GM) function. However, integration standards have yet to be defined; namely, individual fMRI-driven tractography is usually applied and only few studies address group analysis. This work proposes an efficient method of fMRI-driven tractography at group level through the creation of a tractographic atlas starting from the GM areas activated by a verbal fluency task in 11 healthy subjects. The individual tracts were registered to the MNI space. Selection ROIs derived by GM masking and dilation of group activated areas were applied to obtain the fMRI-driven subsets within tracts. An atlas of the tracts recruited among the population was obtained by selecting for each subject the fMRI-guided tracts passing through the high probability voxels (the voxels recruited by the 90% of the subjects) and merging them together. The reliability of this approach was assessed by comparing it with the probabilistic atlas previously introduced in literature. The introduced method allowed to successfully reconstruct activated tracts, which comprehended corpus callosum, left cingulum and arcuate, a small portion of the right arcuate, both cortico-spinal tracts and inferior fronto-occipital fasciculi. Moreover, it proved to give results concordant with the previously introduced probabilistic approach, allowing in addition to reconstruct 3D trajectories of the activated fibers, which appear particularly helpful in the detection of WM connections.

Original languageEnglish
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Pages2283-2286
Number of pages4
DOIs
Publication statusPublished - 2012
Event34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012 - San Diego, CA, United States
Duration: Aug 28 2012Sep 1 2012

Other

Other34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012
CountryUnited States
CitySan Diego, CA
Period8/28/129/1/12

Fingerprint

Atlases
Magnetic Resonance Imaging
Diffusion tensor imaging
Diffusion Tensor Imaging
Corpus Callosum
Merging
Dilatation
Brain
Healthy Volunteers
Trajectories
Fibers
Population
Gray Matter
White Matter

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Preti, M. G., Makris, N., Lagana, M. M., Papadimitriou, G., Baglio, F., Griffanti, L., ... Baselli, G. (2012). A novel approach of fMRI-guided tractography analysis within a group: Construction of an fMRI-guided tractographic atlas. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (pp. 2283-2286). [6346418] https://doi.org/10.1109/EMBC.2012.6346418

A novel approach of fMRI-guided tractography analysis within a group : Construction of an fMRI-guided tractographic atlas. / Preti, Maria Giulia; Makris, Nikos; Lagana, Maria Marcella; Papadimitriou, George; Baglio, Francesca; Griffanti, Ludovica; Nemni, Raffaello; Cecconi, Pietro; Westin, Carl Fredrik; Baselli, Giuseppe.

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2012. p. 2283-2286 6346418.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Preti, MG, Makris, N, Lagana, MM, Papadimitriou, G, Baglio, F, Griffanti, L, Nemni, R, Cecconi, P, Westin, CF & Baselli, G 2012, A novel approach of fMRI-guided tractography analysis within a group: Construction of an fMRI-guided tractographic atlas. in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS., 6346418, pp. 2283-2286, 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012, San Diego, CA, United States, 8/28/12. https://doi.org/10.1109/EMBC.2012.6346418
Preti MG, Makris N, Lagana MM, Papadimitriou G, Baglio F, Griffanti L et al. A novel approach of fMRI-guided tractography analysis within a group: Construction of an fMRI-guided tractographic atlas. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2012. p. 2283-2286. 6346418 https://doi.org/10.1109/EMBC.2012.6346418
Preti, Maria Giulia ; Makris, Nikos ; Lagana, Maria Marcella ; Papadimitriou, George ; Baglio, Francesca ; Griffanti, Ludovica ; Nemni, Raffaello ; Cecconi, Pietro ; Westin, Carl Fredrik ; Baselli, Giuseppe. / A novel approach of fMRI-guided tractography analysis within a group : Construction of an fMRI-guided tractographic atlas. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2012. pp. 2283-2286
@inproceedings{4e84577449bb4c148bb24c6aac2fccdc,
title = "A novel approach of fMRI-guided tractography analysis within a group: Construction of an fMRI-guided tractographic atlas",
abstract = "Diffusion Tensor Imaging (DTI) tractography and functional Magnetic Resonance Imaging (fMRI) investigate two complementary aspects of brain networks: white matter (WM) anatomical connectivity and gray matter (GM) function. However, integration standards have yet to be defined; namely, individual fMRI-driven tractography is usually applied and only few studies address group analysis. This work proposes an efficient method of fMRI-driven tractography at group level through the creation of a tractographic atlas starting from the GM areas activated by a verbal fluency task in 11 healthy subjects. The individual tracts were registered to the MNI space. Selection ROIs derived by GM masking and dilation of group activated areas were applied to obtain the fMRI-driven subsets within tracts. An atlas of the tracts recruited among the population was obtained by selecting for each subject the fMRI-guided tracts passing through the high probability voxels (the voxels recruited by the 90{\%} of the subjects) and merging them together. The reliability of this approach was assessed by comparing it with the probabilistic atlas previously introduced in literature. The introduced method allowed to successfully reconstruct activated tracts, which comprehended corpus callosum, left cingulum and arcuate, a small portion of the right arcuate, both cortico-spinal tracts and inferior fronto-occipital fasciculi. Moreover, it proved to give results concordant with the previously introduced probabilistic approach, allowing in addition to reconstruct 3D trajectories of the activated fibers, which appear particularly helpful in the detection of WM connections.",
author = "Preti, {Maria Giulia} and Nikos Makris and Lagana, {Maria Marcella} and George Papadimitriou and Francesca Baglio and Ludovica Griffanti and Raffaello Nemni and Pietro Cecconi and Westin, {Carl Fredrik} and Giuseppe Baselli",
year = "2012",
doi = "10.1109/EMBC.2012.6346418",
language = "English",
isbn = "9781424441198",
pages = "2283--2286",
booktitle = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",

}

TY - GEN

T1 - A novel approach of fMRI-guided tractography analysis within a group

T2 - Construction of an fMRI-guided tractographic atlas

AU - Preti, Maria Giulia

AU - Makris, Nikos

AU - Lagana, Maria Marcella

AU - Papadimitriou, George

AU - Baglio, Francesca

AU - Griffanti, Ludovica

AU - Nemni, Raffaello

AU - Cecconi, Pietro

AU - Westin, Carl Fredrik

AU - Baselli, Giuseppe

PY - 2012

Y1 - 2012

N2 - Diffusion Tensor Imaging (DTI) tractography and functional Magnetic Resonance Imaging (fMRI) investigate two complementary aspects of brain networks: white matter (WM) anatomical connectivity and gray matter (GM) function. However, integration standards have yet to be defined; namely, individual fMRI-driven tractography is usually applied and only few studies address group analysis. This work proposes an efficient method of fMRI-driven tractography at group level through the creation of a tractographic atlas starting from the GM areas activated by a verbal fluency task in 11 healthy subjects. The individual tracts were registered to the MNI space. Selection ROIs derived by GM masking and dilation of group activated areas were applied to obtain the fMRI-driven subsets within tracts. An atlas of the tracts recruited among the population was obtained by selecting for each subject the fMRI-guided tracts passing through the high probability voxels (the voxels recruited by the 90% of the subjects) and merging them together. The reliability of this approach was assessed by comparing it with the probabilistic atlas previously introduced in literature. The introduced method allowed to successfully reconstruct activated tracts, which comprehended corpus callosum, left cingulum and arcuate, a small portion of the right arcuate, both cortico-spinal tracts and inferior fronto-occipital fasciculi. Moreover, it proved to give results concordant with the previously introduced probabilistic approach, allowing in addition to reconstruct 3D trajectories of the activated fibers, which appear particularly helpful in the detection of WM connections.

AB - Diffusion Tensor Imaging (DTI) tractography and functional Magnetic Resonance Imaging (fMRI) investigate two complementary aspects of brain networks: white matter (WM) anatomical connectivity and gray matter (GM) function. However, integration standards have yet to be defined; namely, individual fMRI-driven tractography is usually applied and only few studies address group analysis. This work proposes an efficient method of fMRI-driven tractography at group level through the creation of a tractographic atlas starting from the GM areas activated by a verbal fluency task in 11 healthy subjects. The individual tracts were registered to the MNI space. Selection ROIs derived by GM masking and dilation of group activated areas were applied to obtain the fMRI-driven subsets within tracts. An atlas of the tracts recruited among the population was obtained by selecting for each subject the fMRI-guided tracts passing through the high probability voxels (the voxels recruited by the 90% of the subjects) and merging them together. The reliability of this approach was assessed by comparing it with the probabilistic atlas previously introduced in literature. The introduced method allowed to successfully reconstruct activated tracts, which comprehended corpus callosum, left cingulum and arcuate, a small portion of the right arcuate, both cortico-spinal tracts and inferior fronto-occipital fasciculi. Moreover, it proved to give results concordant with the previously introduced probabilistic approach, allowing in addition to reconstruct 3D trajectories of the activated fibers, which appear particularly helpful in the detection of WM connections.

UR - http://www.scopus.com/inward/record.url?scp=84870818203&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870818203&partnerID=8YFLogxK

U2 - 10.1109/EMBC.2012.6346418

DO - 10.1109/EMBC.2012.6346418

M3 - Conference contribution

SN - 9781424441198

SP - 2283

EP - 2286

BT - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

ER -