A novel approach of groupwise fMRI-guided Tractography allowing to characterize the clinical evolution of Alzheimer's disease

Maria Giulia Preti, Nikos Makris, George Papadimitriou, Maria Marcella Lagana, Ludovica Griffanti, Mario Clerici, Raffaello Nemni, Carl Fredrik Westin, Giuseppe Baselli, Francesca Baglio

Research output: Contribution to journalArticle

Abstract

Guiding diffusion tract-based anatomy by functional magnetic resonance imaging (fMRI), we aim to investigate the relationship between structural connectivity and functional activity in the human brain. To this purpose, we introduced a novel groupwise fMRI-guided tractographic approach, that was applied on a population ranging between prodromic and moderate stages of Alzheimer's disease (AD). The study comprised of 15 subjects affected by amnestic mild cognitive impairment (aMCI), 14 diagnosed with AD and 14 elderly healthy adults who were used as controls. By creating representative (ensemble) functionally guided tracts within each group of participants, our methodology highlighted the white matter fiber connections involved in verbal fluency functions for a specific population, and hypothesized on brain compensation mechanisms that potentially counteract or reduce cognitive impairment symptoms in prodromic AD. Our hope is that this fMRI-guided tractographic approach could have potential impact in various clinical studies, while investigating white/gray matter connectivity, in both health and disease. Copyright:

Original languageEnglish
Article numbere92026
JournalPLoS One
Volume9
Issue number3
DOIs
Publication statusPublished - Mar 17 2014

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Alzheimer disease
magnetic resonance imaging
Alzheimer Disease
Magnetic Resonance Imaging
Hope
brain
Brain
Neurobehavioral Manifestations
Human Activities
Population
signs and symptoms (animals and humans)
clinical trials
Anatomy
Health
Fibers
Cognitive Dysfunction
White Matter
methodology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

A novel approach of groupwise fMRI-guided Tractography allowing to characterize the clinical evolution of Alzheimer's disease. / Preti, Maria Giulia; Makris, Nikos; Papadimitriou, George; Lagana, Maria Marcella; Griffanti, Ludovica; Clerici, Mario; Nemni, Raffaello; Westin, Carl Fredrik; Baselli, Giuseppe; Baglio, Francesca.

In: PLoS One, Vol. 9, No. 3, e92026, 17.03.2014.

Research output: Contribution to journalArticle

Preti, Maria Giulia ; Makris, Nikos ; Papadimitriou, George ; Lagana, Maria Marcella ; Griffanti, Ludovica ; Clerici, Mario ; Nemni, Raffaello ; Westin, Carl Fredrik ; Baselli, Giuseppe ; Baglio, Francesca. / A novel approach of groupwise fMRI-guided Tractography allowing to characterize the clinical evolution of Alzheimer's disease. In: PLoS One. 2014 ; Vol. 9, No. 3.
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