A novel approach to chronic total occlusions: The crosser system

Gloria Melzi, John Cosgrave, Giuseppe L. Biondi-Zoccai, Flavio Airoldi, Iassen Michev, Alaide Chieffo, Giuseppe M. Sangiorgi, Matteo Montorfano, Mauro Carlino, Antonio Colombo

Research output: Contribution to journalArticlepeer-review


Objectives: To evaluate safety and efficacy of the GROSSER CTO Recanalization System (GROSSER). Background: The GROSSER, a novel device dedicated to recanalization of chronic total occlusions (CTO), relies on a monorail catheter delivering vibrational energy to facilitate the crossing of occluded coronary arteries. Methods: We included de novo or restenotic occlusions in native coronary arteries with typically unfavorable characteristics and a prior failed guidewire attempt either performed in a previous procedure or just before the usage of the CROSSER. The end points analyzed were technical success (ability to cross or facilitate a guidewire crossing into the true lumen), angiographic success (20 mm in 76.6%. The median age of the CTO was 9 months (range 3-60 months). Technical success was obtained in 19 (63%) occlusions and angiographic success in 16 (53%): 26.3% in lesions with prior procedural failure and 73.7% when CROSSER was attempted after initial guidewire failure. Complications were: one guidewire perforation without consequences and one peri-procedural myocardial infarction (MI). No events occurred within 30-day follow-up after discharge. Conclusions: In our experience, the CROSSER System is safe and increases the success of opening CTO refractory to guidewires. This novel device may represent an useful adjunct to the armamentarium of the interventional cardiologist.

Original languageEnglish
Pages (from-to)29-35
Number of pages7
JournalCatheterization and Cardiovascular Interventions
Issue number1
Publication statusPublished - Jul 2006


  • Chronic total occlusion
  • Crosser
  • Guidewire
  • Recanalization device

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging


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