A novel approach to study oxidative stress in thyroid diseases: A preliminary study

Alessio Metere, C. Chiesa, C. Di Cosimo, G. Fierro, L. Giacomelli, D. Pietraforte

Research output: Contribution to journalArticle

Abstract

Background and Objectives: Recently, several Authors have emphasized the relationship between oxidative stress and thyroid tumors. Several methods have been proposed in the literature for the measurement of oxidative stress in human tissues, although the high reactivity and short half life of Reactive Oxygen and Nitrogen Species make difficult their direct determination. Here we propose a novel approach for the determination of oxidative stress in human tissues, taking into account the relationship between free radicals and thyroid diseases. Materials and Methods: Our goal in this preliminary study, was to demonstrate the opportunity to use the coupling of the EPR-spin trapping technique with the hydroxylamine 1-hydroxy-3- carboxy-pyrrolidine, to detect oxidative stress in the human blood of patients with thyroid disease. Results: Our preliminary findings confirm that this is a sensible, precise and valid method to study the oxidative stress and encourage us to continue the project. Conclusions: Our next goal will be to enroll patients affected by different thyroid diseases and to study the effect of some antioxidants in the management of the disease. This will allow to better understand the pathological path that binds the formation of reactive oxidizing species to the thyroid cancer and eventually to take into account the antioxidant therapy, as a possible additional "therapeutic weapon".

Original languageEnglish
Pages (from-to)646-652
Number of pages7
JournalEuropean Review for Medical and Pharmacological Sciences
Volume16
Issue number5
Publication statusPublished - May 2012

Keywords

  • Electron paramagnetic resonance
  • Oxidative stress
  • Thyroid cancer
  • Thyroid diseases

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology (medical)

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    Metere, A., Chiesa, C., Di Cosimo, C., Fierro, G., Giacomelli, L., & Pietraforte, D. (2012). A novel approach to study oxidative stress in thyroid diseases: A preliminary study. European Review for Medical and Pharmacological Sciences, 16(5), 646-652.