A novel approach to systematically implement the universal definition of myocardial infarction: Insights from the CHAMPION PLATFORM trial

Sergio Leonardi, Adriano A M Truffa, Megan L. Neely, Pierluigi Tricoci, Harvey D. White, C. Michael Gibson, Matthew Wilson, Gregg W. Stone, Robert A. Harrington, Deepak L. Bhatt, Kenneth W. Mahaffey

Research output: Contribution to journalArticle

Abstract

Objective To reassess the efficacy of cangrelor efficacy using the universal definition of myocardial infarction (MI). Design We adopted a novel approach to systematically implement the universal definition of MI. Two physicians blinded to treatment allocation reviewed plots of CK-MB and troponin values in relation to time of randomisation and percutaneous coronary intervention (PCI) to identify patients with stable or falling biomarkers pre-PCI (ie, primary cohort), and those with post-PCI CK-MB elevations. Setting The CHAMPION PLATFORM trial. Patients Non-ST-elevation acute coronary syndromes (95%) and stable angina patients (5%). Interventions Cangrelor versus placebo. Main outcome measures The efficacy of cangrelor compared with placebo using the reclassified events (type 4a MI) and the original clinical events committeeadjudicated (CEC PCI-MI) results was investigated. Results Of 5295 patients, 3406 (64.4%) were in the primary cohort. Type 4a MI occurred in 4.3% (226 events/5295 patients) while original CEC PCI-MI occurred in 6.5% (344 events/5295 patients), a significant difference (p

Original languageEnglish
Pages (from-to)1282-1287
Number of pages6
JournalHeart
Volume99
Issue number17
DOIs
Publication statusPublished - Sep 2013

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'A novel approach to systematically implement the universal definition of myocardial infarction: Insights from the CHAMPION PLATFORM trial'. Together they form a unique fingerprint.

  • Cite this

    Leonardi, S., Truffa, A. A. M., Neely, M. L., Tricoci, P., White, H. D., Gibson, C. M., Wilson, M., Stone, G. W., Harrington, R. A., Bhatt, D. L., & Mahaffey, K. W. (2013). A novel approach to systematically implement the universal definition of myocardial infarction: Insights from the CHAMPION PLATFORM trial. Heart, 99(17), 1282-1287. https://doi.org/10.1136/heartjnl-2012-303103