A novel c-kit transcript, potentially encoding a truncated receptor, originates within a kit gene intron in mouse spermatids

Pellegrino Rossi, Giovanna Marziali, Cristina Albanesi, Alexandra Charlesworth, Raffaele Geremia, Vincenzo Sorrentino

Research output: Contribution to journalArticlepeer-review

Abstract

We have cloned a novel c-kit mRNA of 3.2 kb expressed in postmeiotic male germ cells. This transcript initiates in the genomic region immediately upstream of the exon coding for the second box of the split c-kit tyrosine kinase domain. The open reading frame (ORF) contains 12 novel amino acids in frame with the C-terminal 190 amino acids of the c-kit protein. It lacks therefore the upstream region in the 5.5-kb c-kit mRNA encoding the extracellular and transmembrane domain, the ATP-binding site and the kinase insert domain present in the c-kit protein.

Original languageEnglish
Pages (from-to)203-207
Number of pages5
JournalDevelopmental Biology
Volume152
Issue number1
DOIs
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Developmental Biology

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