Abstract
The immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome is characterized by hypogammaglobulinemia and recurrent bacterial infections. Here we report a novel case of ICF syndrome with hypogammaglobulinemia and an inverted CD4/CD8 ratio. Cytogenetically abnormal cells, that were identified in both CD4+ and CD4- peripheral blood lymphocytes, retained their ability to proliferate in vitro following polyclonal stimulation. A primitive defect of B-cell differentiation was detected.
Original language | English |
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Pages (from-to) | 329-331 |
Number of pages | 3 |
Journal | Haematologica |
Volume | 87 |
Issue number | 3 |
Publication status | Published - 2002 |
Keywords
- FISH
- ICF syndrome
- Immunodeficiency
- Juxtacentromeric abnormalities
ASJC Scopus subject areas
- Hematology