A novel group of IncQ1 plasmids conferring multidrug resistance

M. Oliva, R. Monno, P. D'Addabbo, G. Pesole, A. M. Dionisi, M. Scrascia, M. Chiara, D. S. Horner, C. Manzari, I. Luzzi, C. Calia, A. M. D'Erchia, C. Pazzani

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The IncQ is a group of non-conjugative but mobilisable plasmids that are found and stably maintained in a wide range of bacteria contributing to the spread of antimicrobial resistance genes and to the insurgence of multidrug resistant bacteria. Here we report the identification, in clinical Salmonella Typhimurium strains, of an IncQ1 plasmid (pNUC) which confers resistance to sulfamethoxazole, streptomycin and tetracycline through the presence of sul2, strAB and tetA genes, respectively. pNUC was detected in five multidrug resistant S. Typhimurium strains collected in Southern Italy from various hospitals and years of isolation. Bioinformatics analyses highlighted the presence of pNUC-like plasmids in pathogenic bacteria of various Enterobacteriaceae genera or species. Taken as a whole, these plasmids constitute a novel group of IncQ1 plasmids that might have originated through recombination events between a tetR-tetA gene cluster (possibly derived from a Tn1721) and a recipient IncQ1 plasmid related to RSF1010. Our findings raise concerns regarding the possible contribution of the newly identified group of IncQ1 plasmids to the spread of tetracycline resistance.

Original languageEnglish
Pages (from-to)22-26
Number of pages5
JournalPlasmid
Volume89
DOIs
Publication statusPublished - Jan 1 2017

Fingerprint

Multiple Drug Resistance
Plasmids
Salmonella typhimurium
Bacteria
Isolation Hospitals
Tetracycline Resistance
Sulfamethoxazole
Streptomycin
Enterobacteriaceae
Multigene Family
Tetracycline
Computational Biology
Italy
Genetic Recombination
Genes

Keywords

  • IncQ1
  • Multidrug Resistance
  • Plasmid
  • tetA

ASJC Scopus subject areas

  • Molecular Biology

Cite this

A novel group of IncQ1 plasmids conferring multidrug resistance. / Oliva, M.; Monno, R.; D'Addabbo, P.; Pesole, G.; Dionisi, A. M.; Scrascia, M.; Chiara, M.; Horner, D. S.; Manzari, C.; Luzzi, I.; Calia, C.; D'Erchia, A. M.; Pazzani, C.

In: Plasmid, Vol. 89, 01.01.2017, p. 22-26.

Research output: Contribution to journalArticle

Oliva, M, Monno, R, D'Addabbo, P, Pesole, G, Dionisi, AM, Scrascia, M, Chiara, M, Horner, DS, Manzari, C, Luzzi, I, Calia, C, D'Erchia, AM & Pazzani, C 2017, 'A novel group of IncQ1 plasmids conferring multidrug resistance', Plasmid, vol. 89, pp. 22-26. https://doi.org/10.1016/j.plasmid.2016.11.005
Oliva, M. ; Monno, R. ; D'Addabbo, P. ; Pesole, G. ; Dionisi, A. M. ; Scrascia, M. ; Chiara, M. ; Horner, D. S. ; Manzari, C. ; Luzzi, I. ; Calia, C. ; D'Erchia, A. M. ; Pazzani, C. / A novel group of IncQ1 plasmids conferring multidrug resistance. In: Plasmid. 2017 ; Vol. 89. pp. 22-26.
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