A novel HIPEC technique using hybrid CO2 recirculation system: intra-abdominal diffusion test in a porcine model

Stefano Cianci, Giuseppe Vizzielli, Anna Fagotti, Fabio Pacelli, Andrea Di Giorgio, Alessandro Tropea, Antonio Biondi, Giovanni Scambia

Research output: Contribution to journalArticlepeer-review


The role of loco-regional treatment of peritoneal carcinomatosis using intraperitoneal chemotherapy is still investigated. Actually, new technologies are suitable for these procedures, especially a new hybrid system using CO2 called Peritoneal Recirculation System (PRS-1.0 Combat). A HIPEC procedure in a porcine model using the PRS system was conducted. The objective of experimentation was to assess the distribution of liquid inside the abdomen, by using methylene blue instead of chemotherapy. Moreover, we positioned six different thermal probes in different abdominal regions inside the abdomen to measure the temperature during procedure. During the procedure, all thermal probes recorded an average temperature of 41.5°. At the end of infusion, the abdomen was emptied and then opened; the tracer distribution was recorded. No technical problems were recorded during the procedure. Good distribution of tracer was recorded. More studies are needed to investigate better this new technology.

Original languageEnglish
Pages (from-to)529-533
Number of pages5
JournalUpdates in Surgery
Issue number4
Publication statusPublished - Dec 1 2018


  • Carcinosis
  • Loco-regional chemotherapy
  • PRS

ASJC Scopus subject areas

  • Surgery

Fingerprint Dive into the research topics of 'A novel HIPEC technique using hybrid CO<sub>2</sub> recirculation system: intra-abdominal diffusion test in a porcine model'. Together they form a unique fingerprint.

Cite this