A novel integrated platform for the identification of surgical margins in oral squamous cell carcinoma: Results from a prospective single-institution series

Alessandro Baj, Nicola Fusco, Alessandro Bolzoni, Daniela Carioli, Camilla Mazzucato, Alice Faversani, Lorenzo Bresciani, Marco Maggioni, Pasquale Capaccio

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: The optimal surgical margins assessment is capital in oral squamous cell carcinoma (OSCC) management. We evaluated the clinical benefits of integrating intraoperative macroscopic margin (MM) assessment and narrow band imaging (NBI). Methods: Sixteen OSCC patients eligible for surgery were prospectively enrolled. For each patient, 2 to 6 bioptic samples of MM and NBI margins were obtained and histologically analyzed for the presence of dysplasia and lymphocytes. Microvessel density was investigated by CD34 immunohistochemistry. Results: Taken together, 104 specimens were analyzed, including 15% tumors, 33% MM, 33% NBI margins, and 19% MM-NBI overlapping margins. The NBI margins were closer to the lesion in 50% cases, while the same number of MM were more conservative than NBI, irrespective of the tumor site. The rate of histologically positive margins was similar among the two methods, akin to the microvessel density. Conclusions: MM assessment should be integrated but not replaced with the NBI technology to allow for more conservative surgery.

Original languageEnglish
Article number467
JournalBMC Cancer
Volume19
Issue number1
DOIs
Publication statusPublished - May 17 2019

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Narrow Band Imaging
Squamous Cell Carcinoma
Microvessels
Margins of Excision
Neoplasms
Immunohistochemistry
Economics
Lymphocytes
Technology

Keywords

  • Microvascular density
  • Narrow band imaging
  • NBI
  • Oral squamous cell carcinoma
  • Surgical margins

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

Cite this

A novel integrated platform for the identification of surgical margins in oral squamous cell carcinoma : Results from a prospective single-institution series. / Baj, Alessandro; Fusco, Nicola; Bolzoni, Alessandro; Carioli, Daniela; Mazzucato, Camilla; Faversani, Alice; Bresciani, Lorenzo; Maggioni, Marco; Capaccio, Pasquale.

In: BMC Cancer, Vol. 19, No. 1, 467, 17.05.2019.

Research output: Contribution to journalArticle

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AU - Fusco, Nicola

AU - Bolzoni, Alessandro

AU - Carioli, Daniela

AU - Mazzucato, Camilla

AU - Faversani, Alice

AU - Bresciani, Lorenzo

AU - Maggioni, Marco

AU - Capaccio, Pasquale

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N2 - Background: The optimal surgical margins assessment is capital in oral squamous cell carcinoma (OSCC) management. We evaluated the clinical benefits of integrating intraoperative macroscopic margin (MM) assessment and narrow band imaging (NBI). Methods: Sixteen OSCC patients eligible for surgery were prospectively enrolled. For each patient, 2 to 6 bioptic samples of MM and NBI margins were obtained and histologically analyzed for the presence of dysplasia and lymphocytes. Microvessel density was investigated by CD34 immunohistochemistry. Results: Taken together, 104 specimens were analyzed, including 15% tumors, 33% MM, 33% NBI margins, and 19% MM-NBI overlapping margins. The NBI margins were closer to the lesion in 50% cases, while the same number of MM were more conservative than NBI, irrespective of the tumor site. The rate of histologically positive margins was similar among the two methods, akin to the microvessel density. Conclusions: MM assessment should be integrated but not replaced with the NBI technology to allow for more conservative surgery.

AB - Background: The optimal surgical margins assessment is capital in oral squamous cell carcinoma (OSCC) management. We evaluated the clinical benefits of integrating intraoperative macroscopic margin (MM) assessment and narrow band imaging (NBI). Methods: Sixteen OSCC patients eligible for surgery were prospectively enrolled. For each patient, 2 to 6 bioptic samples of MM and NBI margins were obtained and histologically analyzed for the presence of dysplasia and lymphocytes. Microvessel density was investigated by CD34 immunohistochemistry. Results: Taken together, 104 specimens were analyzed, including 15% tumors, 33% MM, 33% NBI margins, and 19% MM-NBI overlapping margins. The NBI margins were closer to the lesion in 50% cases, while the same number of MM were more conservative than NBI, irrespective of the tumor site. The rate of histologically positive margins was similar among the two methods, akin to the microvessel density. Conclusions: MM assessment should be integrated but not replaced with the NBI technology to allow for more conservative surgery.

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KW - Narrow band imaging

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KW - Surgical margins

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