A novel model of acute hepatic failure in dogs with implications for transplantation research

A. Francavilla, L. Makowka, L. Polimeno, M. Barone, J. Demetris, F. W. Guglielmi, G. Ambrosino, D. H. Van Thiel, T. E. Starzl

Research output: Contribution to journalArticle

Abstract

On the basis of studies conducted on an acetaminophen-induced model of hepatotoxicity in large animals that we previously described, we have defined a new model for acute hepatic failure that lends itself to this type of study. Our results report for the first time a model of acute hepatic failure in a large animal that can be easily reproduced in any laboratory. This model satisfies all of the criteria for a suitable animal model of acute hepatic failure. The use of this model in liver transplantation will be useful to better define the clinical indications for orthotopic liver transplantation, and to gain further insight into the pathophysiology of this acute and deadly process.

Original languageEnglish
Pages (from-to)713-715
Number of pages3
JournalTransplantation Proceedings
Volume20
Issue number1 SUPPL. 1
Publication statusPublished - 1988

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ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Francavilla, A., Makowka, L., Polimeno, L., Barone, M., Demetris, J., Guglielmi, F. W., Ambrosino, G., Van Thiel, D. H., & Starzl, T. E. (1988). A novel model of acute hepatic failure in dogs with implications for transplantation research. Transplantation Proceedings, 20(1 SUPPL. 1), 713-715.