Abstract
Even though surgery remains the only potentially curative option for patients with neuroendocrine liver metastases, the factors determining a patient’s prognosis following hepatectomy are poorly understood. Using a multicentric database including patients who underwent hepatectomy for NELMs at seven tertiary referral hepato-biliary-pancreatic centers between January 1990 and December 2014, we sought to identify the predictors of survival and develop a clinical tool to predict patient’s prognosis after liver resection for NELMs. The median age of the 238 patients included in the study was 61.9 years (interquartile range 51.5–70.1) and 55.9 % (n = 133) of patients were men. The number of NELMs (hazard ratio = 1.05), tumor size (HR = 1.01), and Ki-67 index (HR = 1.07) were the predictors of overall survival. These variables were used to develop a nomogram able to predict survival. According to the predicted 5-year OS, patients were divided into three different risk classes: 19.3, 55.5, and 25.2 % of patients were in low (>80 % predicted 5-year OS), medium (40–80 % predicted 5-year OS), and high (70 %) staged and predicted the prognosis of patients undergoing liver resection for NELMs.
| Original language | English |
|---|---|
| Pages (from-to) | 1-8 |
| Number of pages | 8 |
| Journal | Journal of Gastrointestinal Surgery |
| DOIs | |
| Publication status | Accepted/In press - Aug 8 2016 |
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Keywords
- Liver surgery
- Neuroendocrine liver metastasis
- Prognostic model
ASJC Scopus subject areas
- Surgery
- Medicine(all)
- Gastroenterology
Cite this
A Novel Nomogram to Predict the Prognosis of Patients Undergoing Liver Resection for Neuroendocrine Liver Metastasis : an Analysis of the Italian Neuroendocrine Liver Metastasis Database. / Ruzzenente, Andrea; Bagante, Fabio; Bertuzzo, F.; Aldrighetti, Luca; Ercolani, G.; Giuliante, Felice; Ferrero, Alessandro; Torzilli, Guido; Grazi, Gian Luca; Ratti, Francesca; Cucchetti, Alessandro; De Rose, Agostino Maria; Russolillo, Nadia; Cimino, Matteo Maria; Perri, Pasquale; Cataldo, Ivana; Scarpa, Aldo; Guglielmi, Alfredo; Iacono, Calogero.
In: Journal of Gastrointestinal Surgery, 08.08.2016, p. 1-8.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A Novel Nomogram to Predict the Prognosis of Patients Undergoing Liver Resection for Neuroendocrine Liver Metastasis
T2 - an Analysis of the Italian Neuroendocrine Liver Metastasis Database
AU - Ruzzenente, Andrea
AU - Bagante, Fabio
AU - Bertuzzo, F.
AU - Aldrighetti, Luca
AU - Ercolani, G.
AU - Giuliante, Felice
AU - Ferrero, Alessandro
AU - Torzilli, Guido
AU - Grazi, Gian Luca
AU - Ratti, Francesca
AU - Cucchetti, Alessandro
AU - De Rose, Agostino Maria
AU - Russolillo, Nadia
AU - Cimino, Matteo Maria
AU - Perri, Pasquale
AU - Cataldo, Ivana
AU - Scarpa, Aldo
AU - Guglielmi, Alfredo
AU - Iacono, Calogero
PY - 2016/8/8
Y1 - 2016/8/8
N2 - Even though surgery remains the only potentially curative option for patients with neuroendocrine liver metastases, the factors determining a patient’s prognosis following hepatectomy are poorly understood. Using a multicentric database including patients who underwent hepatectomy for NELMs at seven tertiary referral hepato-biliary-pancreatic centers between January 1990 and December 2014, we sought to identify the predictors of survival and develop a clinical tool to predict patient’s prognosis after liver resection for NELMs. The median age of the 238 patients included in the study was 61.9 years (interquartile range 51.5–70.1) and 55.9 % (n = 133) of patients were men. The number of NELMs (hazard ratio = 1.05), tumor size (HR = 1.01), and Ki-67 index (HR = 1.07) were the predictors of overall survival. These variables were used to develop a nomogram able to predict survival. According to the predicted 5-year OS, patients were divided into three different risk classes: 19.3, 55.5, and 25.2 % of patients were in low (>80 % predicted 5-year OS), medium (40–80 % predicted 5-year OS), and high (70 %) staged and predicted the prognosis of patients undergoing liver resection for NELMs.
AB - Even though surgery remains the only potentially curative option for patients with neuroendocrine liver metastases, the factors determining a patient’s prognosis following hepatectomy are poorly understood. Using a multicentric database including patients who underwent hepatectomy for NELMs at seven tertiary referral hepato-biliary-pancreatic centers between January 1990 and December 2014, we sought to identify the predictors of survival and develop a clinical tool to predict patient’s prognosis after liver resection for NELMs. The median age of the 238 patients included in the study was 61.9 years (interquartile range 51.5–70.1) and 55.9 % (n = 133) of patients were men. The number of NELMs (hazard ratio = 1.05), tumor size (HR = 1.01), and Ki-67 index (HR = 1.07) were the predictors of overall survival. These variables were used to develop a nomogram able to predict survival. According to the predicted 5-year OS, patients were divided into three different risk classes: 19.3, 55.5, and 25.2 % of patients were in low (>80 % predicted 5-year OS), medium (40–80 % predicted 5-year OS), and high (70 %) staged and predicted the prognosis of patients undergoing liver resection for NELMs.
KW - Liver surgery
KW - Neuroendocrine liver metastasis
KW - Prognostic model
UR - http://www.scopus.com/inward/record.url?scp=84981206987&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84981206987&partnerID=8YFLogxK
U2 - 10.1007/s11605-016-3228-6
DO - 10.1007/s11605-016-3228-6
M3 - Article
SP - 1
EP - 8
JO - Journal of Gastrointestinal Surgery
JF - Journal of Gastrointestinal Surgery
SN - 1091-255X
ER -