TY - JOUR
T1 - A Novel Nomogram to Predict the Prognosis of Patients Undergoing Liver Resection for Neuroendocrine Liver Metastasis
T2 - an Analysis of the Italian Neuroendocrine Liver Metastasis Database
AU - Ruzzenente, Andrea
AU - Bagante, Fabio
AU - Bertuzzo, F.
AU - Aldrighetti, Luca
AU - Ercolani, G.
AU - Giuliante, Felice
AU - Ferrero, Alessandro
AU - Torzilli, Guido
AU - Grazi, Gian Luca
AU - Ratti, Francesca
AU - Cucchetti, Alessandro
AU - De Rose, Agostino Maria
AU - Russolillo, Nadia
AU - Cimino, Matteo Maria
AU - Perri, Pasquale
AU - Cataldo, Ivana
AU - Scarpa, Aldo
AU - Guglielmi, Alfredo
AU - Iacono, Calogero
PY - 2016/8/8
Y1 - 2016/8/8
N2 - Even though surgery remains the only potentially curative option for patients with neuroendocrine liver metastases, the factors determining a patient’s prognosis following hepatectomy are poorly understood. Using a multicentric database including patients who underwent hepatectomy for NELMs at seven tertiary referral hepato-biliary-pancreatic centers between January 1990 and December 2014, we sought to identify the predictors of survival and develop a clinical tool to predict patient’s prognosis after liver resection for NELMs. The median age of the 238 patients included in the study was 61.9 years (interquartile range 51.5–70.1) and 55.9 % (n = 133) of patients were men. The number of NELMs (hazard ratio = 1.05), tumor size (HR = 1.01), and Ki-67 index (HR = 1.07) were the predictors of overall survival. These variables were used to develop a nomogram able to predict survival. According to the predicted 5-year OS, patients were divided into three different risk classes: 19.3, 55.5, and 25.2 % of patients were in low (>80 % predicted 5-year OS), medium (40–80 % predicted 5-year OS), and high (70 %) staged and predicted the prognosis of patients undergoing liver resection for NELMs.
AB - Even though surgery remains the only potentially curative option for patients with neuroendocrine liver metastases, the factors determining a patient’s prognosis following hepatectomy are poorly understood. Using a multicentric database including patients who underwent hepatectomy for NELMs at seven tertiary referral hepato-biliary-pancreatic centers between January 1990 and December 2014, we sought to identify the predictors of survival and develop a clinical tool to predict patient’s prognosis after liver resection for NELMs. The median age of the 238 patients included in the study was 61.9 years (interquartile range 51.5–70.1) and 55.9 % (n = 133) of patients were men. The number of NELMs (hazard ratio = 1.05), tumor size (HR = 1.01), and Ki-67 index (HR = 1.07) were the predictors of overall survival. These variables were used to develop a nomogram able to predict survival. According to the predicted 5-year OS, patients were divided into three different risk classes: 19.3, 55.5, and 25.2 % of patients were in low (>80 % predicted 5-year OS), medium (40–80 % predicted 5-year OS), and high (70 %) staged and predicted the prognosis of patients undergoing liver resection for NELMs.
KW - Liver surgery
KW - Neuroendocrine liver metastasis
KW - Prognostic model
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U2 - 10.1007/s11605-016-3228-6
DO - 10.1007/s11605-016-3228-6
M3 - Article
SP - 1
EP - 8
JO - Journal of Gastrointestinal Surgery
JF - Journal of Gastrointestinal Surgery
SN - 1091-255X
ER -