A novel p53 mutant in human breast cancer revealed by multiple SSCP analysis

Vincenzo Nigro, Massimo Napolitano, Ciro Abbondanza, Nicola Medici, Annibale Alessandro Puca, Michele Schiavulli, Ignazio Armetta, Bruno Moncharmont, Giovanni Alfredo Puca, Anna Maria Molinari

Research output: Contribution to journalArticlepeer-review

Abstract

DNA from tumor tissue and peripheral blood lymphocytes of primary breast cancer patients was screened for the presence of p53 mutations. In DNA from one tumor we found that the histidine codon 193 (CAT) was somatically converted to arginine (CGT). This aminoacid residue is highly conserved in many species, thus suggesting that such mutation plays an important role in the loss of wt-p53 function.

Original languageEnglish
Pages (from-to)73-75
Number of pages3
JournalCancer Letters
Volume79
Issue number1
DOIs
Publication statusPublished - Apr 29 1994

Keywords

  • Breast cancer
  • Mutation
  • p53
  • SSCP

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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