Abstract
DNA from tumor tissue and peripheral blood lymphocytes of primary breast cancer patients was screened for the presence of p53 mutations. In DNA from one tumor we found that the histidine codon 193 (CAT) was somatically converted to arginine (CGT). This aminoacid residue is highly conserved in many species, thus suggesting that such mutation plays an important role in the loss of wt-p53 function.
Original language | English |
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Pages (from-to) | 73-75 |
Number of pages | 3 |
Journal | Cancer Letters |
Volume | 79 |
Issue number | 1 |
DOIs | |
Publication status | Published - Apr 29 1994 |
Keywords
- Breast cancer
- Mutation
- p53
- SSCP
ASJC Scopus subject areas
- Cancer Research
- Molecular Biology
- Oncology