A novel p53 mutant in human breast cancer revealed by multiple SSCP analysis

Vincenzo Nigro; Massimo Napolitano; Ciro Abbondanza; Nicola Medici; Annibale Alessandro Puca; Michele Schiavulli; Ignazio Armetta; Bruno Moncharmont; Giovanni Alfredo Puca; Anna Maria Molinari

doi:10.1016/0304-3835(94)90065-5

A novel p53 mutant in human breast cancer revealed by multiple SSCP analysis

Vincenzo Nigro, Massimo Napolitano, Ciro Abbondanza, Nicola Medici, Annibale Alessandro Puca, Michele Schiavulli, Ignazio Armetta, Bruno Moncharmont, Giovanni Alfredo Puca, Anna Maria Molinari

IRCCS Multimedica

Research output: Contribution to journal › Article › peer-review

Abstract

DNA from tumor tissue and peripheral blood lymphocytes of primary breast cancer patients was screened for the presence of p53 mutations. In DNA from one tumor we found that the histidine codon 193 (CAT) was somatically converted to arginine (CGT). This aminoacid residue is highly conserved in many species, thus suggesting that such mutation plays an important role in the loss of wt-p53 function.

Original language	English
Pages (from-to)	73-75
Number of pages	3
Journal	Cancer Letters
Volume	79
Issue number	1
DOIs	https://doi.org/10.1016/0304-3835(94)90065-5
Publication status	Published - Apr 29 1994

Keywords

Breast cancer
Mutation
p53
SSCP

ASJC Scopus subject areas

Cancer Research
Molecular Biology
Oncology

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10.1016/0304-3835(94)90065-5

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title = "A novel p53 mutant in human breast cancer revealed by multiple SSCP analysis",

abstract = "DNA from tumor tissue and peripheral blood lymphocytes of primary breast cancer patients was screened for the presence of p53 mutations. In DNA from one tumor we found that the histidine codon 193 (CAT) was somatically converted to arginine (CGT). This aminoacid residue is highly conserved in many species, thus suggesting that such mutation plays an important role in the loss of wt-p53 function.",

keywords = "Breast cancer, Mutation, p53, SSCP",

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doi = "10.1016/0304-3835(94)90065-5",

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T1 - A novel p53 mutant in human breast cancer revealed by multiple SSCP analysis

AU - Nigro, Vincenzo

AU - Napolitano, Massimo

AU - Abbondanza, Ciro

AU - Medici, Nicola

AU - Puca, Annibale Alessandro

AU - Schiavulli, Michele

AU - Armetta, Ignazio

AU - Moncharmont, Bruno

AU - Puca, Giovanni Alfredo

AU - Molinari, Anna Maria

PY - 1994/4/29

Y1 - 1994/4/29

N2 - DNA from tumor tissue and peripheral blood lymphocytes of primary breast cancer patients was screened for the presence of p53 mutations. In DNA from one tumor we found that the histidine codon 193 (CAT) was somatically converted to arginine (CGT). This aminoacid residue is highly conserved in many species, thus suggesting that such mutation plays an important role in the loss of wt-p53 function.

AB - DNA from tumor tissue and peripheral blood lymphocytes of primary breast cancer patients was screened for the presence of p53 mutations. In DNA from one tumor we found that the histidine codon 193 (CAT) was somatically converted to arginine (CGT). This aminoacid residue is highly conserved in many species, thus suggesting that such mutation plays an important role in the loss of wt-p53 function.

KW - Breast cancer

KW - Mutation

KW - p53

KW - SSCP

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JO - Cancer Letters

JF - Cancer Letters

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ER -

A novel p53 mutant in human breast cancer revealed by multiple SSCP analysis

Abstract

Keywords

ASJC Scopus subject areas

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