A novel pathogenic role for microvasculature in inflammatory bowel disease

S. Danese; A. Papa; F. Scaldaferri; C. Graziani; M. Bonizzi; A. Armuzzi; G. Fedeli; G. Gasbarrini; A. Gasbarrini

A novel pathogenic role for microvasculature in inflammatory bowel disease

S. Danese, A. Papa, F. Scaldaferri, C. Graziani, M. Bonizzi, A. Armuzzi, G. Fedeli, G. Gasbarrini, A. Gasbarrini

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Crohn's disease (CD) and ulcerative colitis (UC) are the two major forms of inflammatory bowel disease (IBD). Although their etiology is still unknown, the pathogenic mechanisms underlying intestinal inflammation have made impressive progress in our understanding. In particular, the abnormalities underlying IBD pathogenesis are not restricted to those mediated by classical immune cells such as T and B lymphocytes, macrophages and dendritic cells, but also nonimmune cells. Interestingly, endothelium has become one of the major areas of investigation in gut inflammation.

Original language	English
Pages (from-to)	3-5
Number of pages	3
Journal	European Review for Medical and Pharmacological Sciences
Volume	10
Issue number	1
Publication status	Published - Jan 2006

Keywords

Angiogenesis
Crohn's disease
Inflammatory bowel disease
Ulcerative colitis

ASJC Scopus subject areas

Pharmacology

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abstract = "Crohn's disease (CD) and ulcerative colitis (UC) are the two major forms of inflammatory bowel disease (IBD). Although their etiology is still unknown, the pathogenic mechanisms underlying intestinal inflammation have made impressive progress in our understanding. In particular, the abnormalities underlying IBD pathogenesis are not restricted to those mediated by classical immune cells such as T and B lymphocytes, macrophages and dendritic cells, but also nonimmune cells. Interestingly, endothelium has become one of the major areas of investigation in gut inflammation.",

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AU - Danese, S.

AU - Papa, A.

AU - Scaldaferri, F.

AU - Graziani, C.

AU - Bonizzi, M.

AU - Armuzzi, A.

AU - Fedeli, G.

AU - Gasbarrini, G.

AU - Gasbarrini, A.

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AB - Crohn's disease (CD) and ulcerative colitis (UC) are the two major forms of inflammatory bowel disease (IBD). Although their etiology is still unknown, the pathogenic mechanisms underlying intestinal inflammation have made impressive progress in our understanding. In particular, the abnormalities underlying IBD pathogenesis are not restricted to those mediated by classical immune cells such as T and B lymphocytes, macrophages and dendritic cells, but also nonimmune cells. Interestingly, endothelium has become one of the major areas of investigation in gut inflammation.

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KW - Crohn's disease

KW - Inflammatory bowel disease

KW - Ulcerative colitis

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