A novel pathway links telomeres to NK-cell activity: Implications for immunotherapy

Julien Cherfils-Vicini, Pasquale Zizza, Eric Gilson, Annamaria Biroccio

Research output: Contribution to journalArticle

Abstract

Here, we describe a model in which telomeric repeat-binding factor 2 (TERF2) can control tumorigenesis not only via cancer cell-intrinsic mechanisms but also via non-cancer cell autonomous pathways. Indeed, we have recently shown that TERF2 regulates tissue homeostasis as it promotes the elimination of aged, damaged, and neoplastic cells by the immune system, opening the way to new therapeutic options against cancer.

Original languageEnglish
Article numbere27358
JournalOncoImmunology
Volume3
Issue number1
DOIs
Publication statusPublished - 2014

Keywords

  • Immunosurveillance
  • NK cells
  • Telomeres
  • TERF2
  • Tumorigenesis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

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