A Novel Protective Role for FXR against Inflammasome Activation and Endotoxemia

Oihane Garcia-Irigoyen, Antonio Moschetta

Research output: Contribution to journalShort survey

Abstract

During conditions of impaired bile flow (cholestasis), increased serum bile acids (BAs) are prognostic markers of sepsis. In this issue, Hao et al. (2017) show that the BA receptor FXR binds NLRP3 inflammasome in macrophages and inhibits activation of inflammasome components, thus reducing endotoxemia in cholestasis.

Original languageEnglish
Pages (from-to)763-764
Number of pages2
JournalCell Metabolism
Volume25
Issue number4
DOIs
Publication statusPublished - Apr 4 2017

Keywords

  • bile acids
  • cholestasis
  • FXR
  • inflammasome
  • nuclear receptors
  • sepsis

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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