A novel source of tetraploid cancer cell precursors: Telomere insufficiency links aging to oncogenesis

M. Castedo, I. Vitale, G. Kroemer

Research output: Contribution to journalArticle

Abstract

Epithelial cancers of the elderly are caused by a combination of telomere dysfunction and the mutational invalidation of major tumor suppressors including p53. A recent article published in Cell by Davoli et al. shows that the simultaneous elimination of p53 and telomerase causes a state of chronic DNA damage that results in tetraploidization through endoreplication, that is, two consecutive S phases that are not separated by mitosis. As tetraploid cells represent a metastable intermediate between normal diploidy and cancer-associated aneuploidy, this novel route to tetraploidization may constitute (one of) the functional link(s) between aging and carcinogenesis.

Original languageEnglish
Pages (from-to)5869-5872
Number of pages4
JournalOncogene
Volume29
Issue number44
DOIs
Publication statusPublished - Nov 4 2010

Keywords

  • aging
  • oncogenesis
  • telomere
  • tetraploidy

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

Fingerprint Dive into the research topics of 'A novel source of tetraploid cancer cell precursors: Telomere insufficiency links aging to oncogenesis'. Together they form a unique fingerprint.

  • Cite this