A novel strategy to enhance mesenchymal stem cell migration capacity and promote tissue repair in an injury specific fashion

Christodoulos Xinaris, M. Morigi, V. Benedetti, B. Imberti, A. S. Fabricio, E. Squarcina, A. Benigni, E. Gagliardini, G. Remuzzi

Research output: Contribution to journalArticle

Abstract

Mesenchymal stem cells (MSCs) of bone marrow origin appear to be an attractive candidate for cell-based therapies. However, the major barrier to the effective implementation of MSC-based therapies is the lack of specific homing of exogenously infused cells and overall the inability to drive them to the diseased or damaged tissue. In order to circumvent these limitations, we developed a preconditioning strategy to optimize MSC migration efficiency and potentiate their beneficial effect at the site of injury. Initially, we screened different molecules by using an in vitro injury-migration setting, and subsequently, we evaluated the effectiveness of the different strategies in mice with acute kidney injury (AKI). Our results showed that preconditioning of MSCs with IGF-1 before infusion improved cell migration capacity and restored normal renal function after AKI. The present study demonstrates that promoting migration of MSCs could increase their therapeutic potential and indicates a new therapeutic paradigm for organ repair.

Original languageEnglish
Pages (from-to)423-436
Number of pages14
JournalCell Transplantation
Volume22
Issue number3
DOIs
Publication statusPublished - 2013

Keywords

  • Acute kidney injury (AKI)
  • Insulin-like growth factor-1 (IGF-1)
  • Kidney repair
  • Mesenchymal stem cells (MSCs)
  • Migration

ASJC Scopus subject areas

  • Cell Biology
  • Transplantation
  • Biomedical Engineering

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