A novel t(2;3)(p11;q27) in a case of follicular lymphoma

Cinzia Tapinassi; Carla Micucci; Idoya Lahortiga; Omar Malazzi; Patrizia Gasparini; Ana Gorosquieta; Maria D. Odero; Elena Belloni

doi:10.1016/j.cancergencyto.2006.07.017

A novel t(2;3)(p11;q27) in a case of follicular lymphoma

Cinzia Tapinassi, Carla Micucci, Idoya Lahortiga, Omar Malazzi, Patrizia Gasparini, Ana Gorosquieta, Maria D. Odero, Elena Belloni

Research output: Contribution to journal › Article › peer-review

Abstract

Rearrangement of the BCL6 gene is found in follicular lymphomas and in diffuse large B cell lymphomas of follicular center cell origin. The breakpoints cluster mainly in a region spanning the first noncoding exon of the gene (the major breakpoint region). A second breakpoint cluster has also been identified upstream of the first BCL6 noncoding exon (the alternative breakpoint region [ABR]). To date, eight different rearrangements involving the ABR have been reported. Here, we describe a novel rearrangement involving a t(2;3)(p11;q27) translocation that affects the ABR in an unusual combination with the IGK locus.

Original language	English
Pages (from-to)	70-73
Number of pages	4
Journal	Cancer Genetics and Cytogenetics
Volume	172
Issue number	1
DOIs	https://doi.org/10.1016/j.cancergencyto.2006.07.017
Publication status	Published - Jan 1 2007

ASJC Scopus subject areas

Cancer Research
Genetics
Molecular Biology

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10.1016/j.cancergencyto.2006.07.017

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abstract = "Rearrangement of the BCL6 gene is found in follicular lymphomas and in diffuse large B cell lymphomas of follicular center cell origin. The breakpoints cluster mainly in a region spanning the first noncoding exon of the gene (the major breakpoint region). A second breakpoint cluster has also been identified upstream of the first BCL6 noncoding exon (the alternative breakpoint region [ABR]). To date, eight different rearrangements involving the ABR have been reported. Here, we describe a novel rearrangement involving a t(2;3)(p11;q27) translocation that affects the ABR in an unusual combination with the IGK locus.",

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AU - Tapinassi, Cinzia

AU - Micucci, Carla

AU - Lahortiga, Idoya

AU - Malazzi, Omar

AU - Gasparini, Patrizia

AU - Gorosquieta, Ana

AU - Odero, Maria D.

AU - Belloni, Elena

PY - 2007/1/1

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AB - Rearrangement of the BCL6 gene is found in follicular lymphomas and in diffuse large B cell lymphomas of follicular center cell origin. The breakpoints cluster mainly in a region spanning the first noncoding exon of the gene (the major breakpoint region). A second breakpoint cluster has also been identified upstream of the first BCL6 noncoding exon (the alternative breakpoint region [ABR]). To date, eight different rearrangements involving the ABR have been reported. Here, we describe a novel rearrangement involving a t(2;3)(p11;q27) translocation that affects the ABR in an unusual combination with the IGK locus.

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A novel t(2;3)(p11;q27) in a case of follicular lymphoma

Abstract

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