A novel t(2;3)(p11;q27) in a case of follicular lymphoma

Cinzia Tapinassi, Carla Micucci, Idoya Lahortiga, Omar Malazzi, Patrizia Gasparini, Ana Gorosquieta, Maria D. Odero, Elena Belloni

Research output: Contribution to journalArticlepeer-review

Abstract

Rearrangement of the BCL6 gene is found in follicular lymphomas and in diffuse large B cell lymphomas of follicular center cell origin. The breakpoints cluster mainly in a region spanning the first noncoding exon of the gene (the major breakpoint region). A second breakpoint cluster has also been identified upstream of the first BCL6 noncoding exon (the alternative breakpoint region [ABR]). To date, eight different rearrangements involving the ABR have been reported. Here, we describe a novel rearrangement involving a t(2;3)(p11;q27) translocation that affects the ABR in an unusual combination with the IGK locus.

Original languageEnglish
Pages (from-to)70-73
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume172
Issue number1
DOIs
Publication statusPublished - Jan 1 2007

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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