TY - JOUR
T1 - A novel Zip2 Gln/Arg/Leu codon 2 polymorphism is associated with carotid artery disease in aging
AU - Giacconi, Robertina
AU - Muti, Elisa
AU - Malavolta, Marco
AU - Cardelli, Maurizio
AU - Pierpaoli, Sara
AU - Cipriano, Catia
AU - Costarelli, Laura
AU - Tesei, Silvia
AU - Saba, Vittorio
AU - Mocchegiani, Eugenio
PY - 2008/4/1
Y1 - 2008/4/1
N2 - Zinc deficiency represents a risk factor for carotid stenosis (CS) development. In mammals, members of the ZIP family regulate zinc uptake, and hZip2 is a human zinc importer upregulated by zinc depletion. The purpose of this study was to investigate the association of a novel Zip2 Gln/Arg/Leu codon 2 polymorphism with CS, analyzing 250 CS patients and 259 elderly controls. CS patients showed an increased GG genotype frequency (60% vs. 47.5%), and a reduced TT frequency (6% vs. 10%) (p <0.05 by χ2 test). In conclusion, Zip2 Gln/Arg/Leu polymorphism plays a role in the susceptibility to carotid artery disease.
AB - Zinc deficiency represents a risk factor for carotid stenosis (CS) development. In mammals, members of the ZIP family regulate zinc uptake, and hZip2 is a human zinc importer upregulated by zinc depletion. The purpose of this study was to investigate the association of a novel Zip2 Gln/Arg/Leu codon 2 polymorphism with CS, analyzing 250 CS patients and 259 elderly controls. CS patients showed an increased GG genotype frequency (60% vs. 47.5%), and a reduced TT frequency (6% vs. 10%) (p <0.05 by χ2 test). In conclusion, Zip2 Gln/Arg/Leu polymorphism plays a role in the susceptibility to carotid artery disease.
UR - http://www.scopus.com/inward/record.url?scp=42649111666&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=42649111666&partnerID=8YFLogxK
U2 - 10.1089/rej.2008.0671
DO - 10.1089/rej.2008.0671
M3 - Article
C2 - 18328005
AN - SCOPUS:42649111666
VL - 11
SP - 297
EP - 300
JO - Rejuvenation Research
JF - Rejuvenation Research
SN - 1549-1684
IS - 2
ER -