A novel Zip2 Gln/Arg/Leu codon 2 polymorphism is associated with carotid artery disease in aging

Robertina Giacconi, Elisa Muti, Marco Malavolta, Maurizio Cardelli, Sara Pierpaoli, Catia Cipriano, Laura Costarelli, Silvia Tesei, Vittorio Saba, Eugenio Mocchegiani

Research output: Contribution to journalArticlepeer-review

Abstract

Zinc deficiency represents a risk factor for carotid stenosis (CS) development. In mammals, members of the ZIP family regulate zinc uptake, and hZip2 is a human zinc importer upregulated by zinc depletion. The purpose of this study was to investigate the association of a novel Zip2 Gln/Arg/Leu codon 2 polymorphism with CS, analyzing 250 CS patients and 259 elderly controls. CS patients showed an increased GG genotype frequency (60% vs. 47.5%), and a reduced TT frequency (6% vs. 10%) (p <0.05 by χ2 test). In conclusion, Zip2 Gln/Arg/Leu polymorphism plays a role in the susceptibility to carotid artery disease.

Original languageEnglish
Pages (from-to)297-300
Number of pages4
JournalRejuvenation Research
Volume11
Issue number2
DOIs
Publication statusPublished - Apr 1 2008

ASJC Scopus subject areas

  • Ageing

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