A one year study of new lesions in multiple sclerosis using monthly gadolinium enhanced MRI: Correlations with changes of T2 and magnetization transfer lesion loads

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Abstract

In this study, 14 patients with either relapsing-remitting or secondary progressive multiple sclerosis (MS) were scanned monthly using gadolinium enhanced magnetic resonance imaging (MRI). At the start of the study and at 1 year follow up, T2-weighted and magnetization transfer (MT) scans were also performed. The correlation between the frequency and extent of enhancement and changes of lesion load over a 1 year period on T2-weighted and MT images were assessed. For all patients, and for the relapsing-remitting patients only, the number and volume of enhancing lesions per month showed no significant correlation with the change between baseline and 1 year follow up of lesion volumes on T2 and MT images. However, strong correlations were found between the number and volume of gadolinium enhancing lesions with changes of T2 (r=0.93, P=0.02) and MT (r=0.82, P=0.04) lesion loads in patients with secondary progressive MS. Strong correlations were also found between the lesion loads on T2-weighted scans and on MT images both at baseline and at 1 year follow up (r=0.83, P=0.003). In addition, the changes in lesion load over 1 year, detected using the two techniques, were moderately correlated (r=0.51, P=0.05). This study provides further evidence that the pathological processes in MS are at different stages in relapsing- remitting and secondary progressive MS. It also suggests that the effectiveness of recovery mechanisms within lesions might be one of the major factors responsible for such a difference.

Original languageEnglish
Pages (from-to)203-208
Number of pages6
JournalJournal of the Neurological Sciences
Volume158
Issue number2
DOIs
Publication statusPublished - Jun 30 1998

Keywords

  • Magnetic resonance imaging
  • Magnetization transfer imaging
  • Multiple sclerosis
  • Reparative mechanisms

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

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