TY - JOUR
T1 - A parallel randomized trial on the effect of a healthful diet on inflammageing and its consequences in European elderly people
T2 - Design of the NU-AGE dietary intervention study
AU - Berendsen, Agnes
AU - Santoro, Aurelia
AU - Pini, Elisa
AU - Cevenini, Elisa
AU - Ostan, Rita
AU - Pietruszka, Barbara
AU - Rolf, Katarzyna
AU - Cano, Noël
AU - Caille, Aurélie
AU - Lyon-Belgy, Noëlle
AU - Fairweather-Tait, Susan
AU - Feskens, Edith
AU - Franceschi, Claudio
AU - de Groot, C. P G M
PY - 2014
Y1 - 2014
N2 - Background: The proportion of European elderly is expected to increase to 30% in 2060. Combining dietary components may modulate many processes involved in ageing. So, it is likely that a healthful diet approach might have greater favourable impact on age-related decline than individual dietary components. This paper describes the design of a healthful diet intervention on inflammageing and its consequences in the elderly. Methods: The NU-AGE study is a parallel randomized one-year trial in 1250 apparently healthy, independently living European participants aged 65-80 years. Participants are randomised into either the diet group or control group. Participants in the diet group received dietary advice aimed at meeting the nutritional requirements of the ageing population. Special attention was paid to nutrients that may be inadequate or limiting in diets of elderly, such as vitamin D, vitamin B12, and calcium.C-reactive protein is measured as primary outcome. Discussion: The NU-AGE study is the first dietary intervention investigating the effect of a healthful diet providing targeted nutritional recommendations for optimal health and quality of life in apparently healthy European elderly. Results of this intervention will provide evidence on the effect of a healthful diet on the prevention of age related decline.
AB - Background: The proportion of European elderly is expected to increase to 30% in 2060. Combining dietary components may modulate many processes involved in ageing. So, it is likely that a healthful diet approach might have greater favourable impact on age-related decline than individual dietary components. This paper describes the design of a healthful diet intervention on inflammageing and its consequences in the elderly. Methods: The NU-AGE study is a parallel randomized one-year trial in 1250 apparently healthy, independently living European participants aged 65-80 years. Participants are randomised into either the diet group or control group. Participants in the diet group received dietary advice aimed at meeting the nutritional requirements of the ageing population. Special attention was paid to nutrients that may be inadequate or limiting in diets of elderly, such as vitamin D, vitamin B12, and calcium.C-reactive protein is measured as primary outcome. Discussion: The NU-AGE study is the first dietary intervention investigating the effect of a healthful diet providing targeted nutritional recommendations for optimal health and quality of life in apparently healthy European elderly. Results of this intervention will provide evidence on the effect of a healthful diet on the prevention of age related decline.
KW - Ageing
KW - Elderly
KW - Intervention
KW - Nutrition
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U2 - 10.1016/j.mad.2013.10.002
DO - 10.1016/j.mad.2013.10.002
M3 - Article
C2 - 24211360
AN - SCOPUS:84891555279
VL - 134
SP - 523
EP - 530
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
SN - 0047-6374
IS - 11-12
ER -