A paraoxonase gene polymorphism, PON 1 (55), as an independent risk factor for increased carotid intima-media thickness in middle-aged women

Giuliana Fortunato, Paolo Rubba, Salvatore Panico, Daniela Trono, Nadia Tinto, Cristina Mazzaccara, Mario De Michele, Arcangelo Iannuzzi, Dino F. Vitale, Francesco Salvatore, Lucia Sacchetti

Research output: Contribution to journalArticlepeer-review

Abstract

Paraoxonase (PON) gene polymorphisms have been proposed as genetic markers of risk for cardiovascular disease (CVD). Sporadic results suggest they are correlated with intima-media thickness (IMT), an indicator of preclinical atherosclerotic disease. We have investigated whether polymorphisms PON 1 (M/L) 55, (Q/R) 192, PON 2 (S/C) 311 are related to site-specific carotid plaques in 310 middle-aged women. Subjects were also investigated for physical and biochemical parameters including oxidative markers to evaluate their effect on development of atherosclerotic plaques (IMT>1.2 mm) identified by high resolution B-mode ultrasound. We demonstrate that PON 1 (LL+ML) 55 is associated with plaques both at the bifurcation (OR=2.40; 95% CI 1.00-5.90) and at the common carotid artery (OR=2.75; 95% CI 1.01-7.50), and to the total number of plaques at any site (P

Original languageEnglish
Pages (from-to)141-148
Number of pages8
JournalAtherosclerosis
Volume167
Issue number1
DOIs
Publication statusPublished - Mar 1 2003

Keywords

  • Carotid atherosclerosis
  • Intima-media thickness
  • Oxidation markers
  • PON 1 and 2 polymorphisms
  • Women

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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