A paraoxonase gene polymorphism, PON 1 (55), as an independent risk factor for increased carotid intima-media thickness in middle-aged women

Giuliana Fortunato; Paolo Rubba; Salvatore Panico; Daniela Trono; Nadia Tinto; Cristina Mazzaccara; Mario De Michele; Arcangelo Iannuzzi; Dino F. Vitale; Francesco Salvatore; Lucia Sacchetti

doi:10.1016/S0021-9150(02)00423-9

A paraoxonase gene polymorphism, PON 1 (55), as an independent risk factor for increased carotid intima-media thickness in middle-aged women

Giuliana Fortunato, Paolo Rubba, Salvatore Panico, Daniela Trono, Nadia Tinto, Cristina Mazzaccara, Mario De Michele, Arcangelo Iannuzzi, Dino F. Vitale, Francesco Salvatore, Lucia Sacchetti

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Contribution to journal › Article › peer-review

Abstract

Paraoxonase (PON) gene polymorphisms have been proposed as genetic markers of risk for cardiovascular disease (CVD). Sporadic results suggest they are correlated with intima-media thickness (IMT), an indicator of preclinical atherosclerotic disease. We have investigated whether polymorphisms PON 1 (M/L) 55, (Q/R) 192, PON 2 (S/C) 311 are related to site-specific carotid plaques in 310 middle-aged women. Subjects were also investigated for physical and biochemical parameters including oxidative markers to evaluate their effect on development of atherosclerotic plaques (IMT>1.2 mm) identified by high resolution B-mode ultrasound. We demonstrate that PON 1 (LL+ML) 55 is associated with plaques both at the bifurcation (OR=2.40; 95% CI 1.00-5.90) and at the common carotid artery (OR=2.75; 95% CI 1.01-7.50), and to the total number of plaques at any site (P

Original language	English
Pages (from-to)	141-148
Number of pages	8
Journal	Atherosclerosis
Volume	167
Issue number	1
DOIs	https://doi.org/10.1016/S0021-9150(02)00423-9
Publication status	Published - Mar 1 2003

Keywords

Carotid atherosclerosis
Intima-media thickness
Oxidation markers
PON 1 and 2 polymorphisms
Women

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/S0021-9150(02)00423-9

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Fortunato, G., Rubba, P., Panico, S., Trono, D., Tinto, N., Mazzaccara, C., De Michele, M., Iannuzzi, A., Vitale, D. F., Salvatore, F., & Sacchetti, L. (2003). A paraoxonase gene polymorphism, PON 1 (55), as an independent risk factor for increased carotid intima-media thickness in middle-aged women. Atherosclerosis, 167(1), 141-148. https://doi.org/10.1016/S0021-9150(02)00423-9

A paraoxonase gene polymorphism, PON 1 (55), as an independent risk factor for increased carotid intima-media thickness in middle-aged women. / Fortunato, Giuliana; Rubba, Paolo; Panico, Salvatore; Trono, Daniela; Tinto, Nadia; Mazzaccara, Cristina; De Michele, Mario; Iannuzzi, Arcangelo; Vitale, Dino F.; Salvatore, Francesco; Sacchetti, Lucia.

In: Atherosclerosis, Vol. 167, No. 1, 01.03.2003, p. 141-148.

Research output: Contribution to journal › Article › peer-review

Fortunato, G, Rubba, P, Panico, S, Trono, D, Tinto, N, Mazzaccara, C, De Michele, M, Iannuzzi, A, Vitale, DF, Salvatore, F & Sacchetti, L 2003, 'A paraoxonase gene polymorphism, PON 1 (55), as an independent risk factor for increased carotid intima-media thickness in middle-aged women', Atherosclerosis, vol. 167, no. 1, pp. 141-148. https://doi.org/10.1016/S0021-9150(02)00423-9

Fortunato, Giuliana ; Rubba, Paolo ; Panico, Salvatore ; Trono, Daniela ; Tinto, Nadia ; Mazzaccara, Cristina ; De Michele, Mario ; Iannuzzi, Arcangelo ; Vitale, Dino F. ; Salvatore, Francesco ; Sacchetti, Lucia. / A paraoxonase gene polymorphism, PON 1 (55), as an independent risk factor for increased carotid intima-media thickness in middle-aged women. In: Atherosclerosis. 2003 ; Vol. 167, No. 1. pp. 141-148.

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