TY - JOUR
T1 - A paraoxonase gene polymorphism, PON 1 (55), as an independent risk factor for increased carotid intima-media thickness in middle-aged women
AU - Fortunato, Giuliana
AU - Rubba, Paolo
AU - Panico, Salvatore
AU - Trono, Daniela
AU - Tinto, Nadia
AU - Mazzaccara, Cristina
AU - De Michele, Mario
AU - Iannuzzi, Arcangelo
AU - Vitale, Dino F.
AU - Salvatore, Francesco
AU - Sacchetti, Lucia
PY - 2003/3/1
Y1 - 2003/3/1
N2 - Paraoxonase (PON) gene polymorphisms have been proposed as genetic markers of risk for cardiovascular disease (CVD). Sporadic results suggest they are correlated with intima-media thickness (IMT), an indicator of preclinical atherosclerotic disease. We have investigated whether polymorphisms PON 1 (M/L) 55, (Q/R) 192, PON 2 (S/C) 311 are related to site-specific carotid plaques in 310 middle-aged women. Subjects were also investigated for physical and biochemical parameters including oxidative markers to evaluate their effect on development of atherosclerotic plaques (IMT>1.2 mm) identified by high resolution B-mode ultrasound. We demonstrate that PON 1 (LL+ML) 55 is associated with plaques both at the bifurcation (OR=2.40; 95% CI 1.00-5.90) and at the common carotid artery (OR=2.75; 95% CI 1.01-7.50), and to the total number of plaques at any site (P
AB - Paraoxonase (PON) gene polymorphisms have been proposed as genetic markers of risk for cardiovascular disease (CVD). Sporadic results suggest they are correlated with intima-media thickness (IMT), an indicator of preclinical atherosclerotic disease. We have investigated whether polymorphisms PON 1 (M/L) 55, (Q/R) 192, PON 2 (S/C) 311 are related to site-specific carotid plaques in 310 middle-aged women. Subjects were also investigated for physical and biochemical parameters including oxidative markers to evaluate their effect on development of atherosclerotic plaques (IMT>1.2 mm) identified by high resolution B-mode ultrasound. We demonstrate that PON 1 (LL+ML) 55 is associated with plaques both at the bifurcation (OR=2.40; 95% CI 1.00-5.90) and at the common carotid artery (OR=2.75; 95% CI 1.01-7.50), and to the total number of plaques at any site (P
KW - Carotid atherosclerosis
KW - Intima-media thickness
KW - Oxidation markers
KW - PON 1 and 2 polymorphisms
KW - Women
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U2 - 10.1016/S0021-9150(02)00423-9
DO - 10.1016/S0021-9150(02)00423-9
M3 - Article
C2 - 12618279
AN - SCOPUS:12244283743
VL - 167
SP - 141
EP - 148
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
IS - 1
ER -