A pathological complete response after preoperative chemotherapy with carboplatin and pemetrexed in malignant pleural mesothelioma: A case report

Giulia Pasello, Giuseppe Altavilla, Laura Bonanno, Federico Rea, Adolfo Gino Favaretto

Research output: Contribution to journalArticlepeer-review

Abstract

Malignant pleural mesothelioma is an aggressive tumour with poor prognosis and short duration of response probably due to the high chemo-refractoriness. Multimodality treatment based on preoperative chemotherapy, surgery and adjuvant radiotherapy seems to be a feasible and effective therapeutic option in selected patients.We report on a case of pathological complete response in a patient affected by malignant pleural mesothelioma who was treated with four cycles of preoperative chemotherapy based on carboplatin plus pemetrexed followed by parietal pleurectomy and lung decortication. Carboplatin plus pemetrexed was a well tolerated regimen without grade 3-4 haematological toxicity, and this confirm the feasibility of such a treatment as an alternative to the current golden standard based on cisplatin plus pemetrexed.Complete resection allows the pathologist to better describe biological markers of mesothelioma cells, in order to select patients with different treatment outcome and prognosis.

Original languageEnglish
Pages (from-to)254-257
Number of pages4
JournalJournal of Thoracic Disease
Volume2
Issue number4
DOIs
Publication statusPublished - 2010

Keywords

  • Carboplatin
  • Chemotherapy
  • Mesothelioma
  • Pemetrexed

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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