A patient with AL amyloidosis with negative free light chain results

Paolo Milani, Veronica Valentini, Giovanni Ferraro, Marco Basset, Francesca Russo, Andrea Foli, Giovanni Palladini, Giampaolo Merlini

Research output: Contribution to journalArticlepeer-review

Abstract

The detection and quantification of amyloidogenic monoclonal light chains are necessary for the diagnosis and evaluation of response to treatment in AL amyloidosis. However, the amyloid clone is often small and difficult to detect. We report the case of a 68-year-old man who was referred to our Center in April 2013 after syncope and the identification of left ventricular hypertrophy at echocardiography, suspected for amyloidosis. A commercial agarose gel electrophoresis immunofixation (IFE) did not reveal monoclonal components in serum and urine. The κ serum free light chain (FLC) concentration was 21.5 mg/L, λ 33 mg/L (κ/λ ratio 0.65), NT-proBNP 9074 ng/L (u.r.l.

Original languageEnglish
Pages (from-to)1035-1037
Number of pages3
JournalClinical Chemistry and Laboratory Medicine
Volume54
Issue number6
DOIs
Publication statusPublished - Jun 1 2016

Keywords

  • amyloidosis
  • free light chain
  • immunofixation

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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