A peripheral neuropathy associated with parkinsonian syndrome: A case report

The occurence of clinical features of Parkinsonian syndrome in patients with pre-existing peripheral neuropathy (PN) resembling Charcot-MarieTooth disease has been seldom reported. We describe a new observation of peripheral neuropathy associated with parkinsonian syndrome. A 67-year- old man with a positive familial pes cavus and distal muscolar atrophy developed from the age of 38 a progressive distal polineuropathy. From the age of 60 a L-Dopa sensitive parkinsonian syndrome (PS) appeared. Electrophysiological and bioptic findings were consistent with a predominantly axonal neuropathy. According to Jaradeh and Dyck (1992) and Tranchant et al. (1994) descriptions, the association PN-PS seems to be a different disorder from Machado-Joseph type IV disease, and may represent a new entity among movement disorders.